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Type 2 Diabetes Blood Sugar Control and Weight Loss Study

A research study to see how well CagriSema compared to semaglutide, cagrilintide and placebo lowers blood sugar and body weight in people with type 2 diabetes treated with metformin with or without an SGLT2 inhibitor

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

You will need to self-inject study medication once weekly, attend some visits fasting, and complete questionnaires. You will also need to use a highly effective method of contraception if you are of childbearing potential. You will be asked to wear a blinded continuous glucose monitoring device (Dexcom CGM) for 20 days at a time at 3 separate points during the study. The study also involves 14 blood draws, 3 eye exams, and 4 EKGs.

Incentives

Information provided upon request

In-person visits:
14-19

Phone or online visits:
8

Total length of participation:
1.5 years

Looking for Specific Volunteers

Able to participate:

You were diagnosed with Type 2 diabetes at least 6 months ago
You have been on a stable dose of your diabetes medications for at least 3 months
Your blood sugar is still elevated (HbA1c of 7-10.5%)
You have a BMI of at least 25 (overweight or obese)

Not eligible if:

You take any medication for diabetes, other than metformin or an SGLT2 inhibitor (Jardiance, Farxiga, Invokana, etc)
You take any medications for weight loss (semaglutide, tirzepitide, phentermine, etc.)
You have had a weight loss procedure that has not been reversed
You are pregnant, breast-feeding, intend to become pregnant during the study period, or are unwilling to use highly effective contraception
You have other unstable or critical chronic illnesses

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

John Buse
Medicine-Endocrinology

Study Type

Clinical or Medical
Interventional

Study Topics

Diabetes
Obesity

IRB Number

23-1333

ClinicalTrials.gov

NCT06065540

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