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Advanced Inoperable Non-Small Cell Lung Cancer Study

This is a phase III trial to compare the usual treatment for Locally Advanced Non-Small Cell Lung Cancer to the use of stereotactic body radiation therapy (SBRT) in addition to the usual treatment. SBRT is already commonly used in lung cancer treatment, but it has not routinely been added to the usual combination of radiation, chemotherapy, and immune therapy that doctors normally use. This study will help the study doctors find out if this different approach is better, the same, or worse than the usual approach.

Age & Gender

  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)

Location

North Carolina (Orange)

What will be asked of you

If you take part in this study, you will meet frequently with a member of the study team in addition to your oncology care team. The study involves a routine blood work and diagnostic tests. Treatment will be determined by using a computer to assign you to one of the study groups. There are two group in this study. If you are assigned to group 1, you will receive the standard treatment of radiation and chemotherapy, followed by immune therapy. If you are assigned to group 2, you will receive SBRT for about 1-2 weeks before starting the standard treatment of radiation and chemotherapy, followed by immune therapy. You will also be asked to fill out some surveys about your physical and emotional well-being and your symptoms.

Total length of participation:
Approximately 48 months

Looking for Specific Volunteers

Able to participate:

  • You have a been diagnosed stage II or III non-small cell lung cancer (NSCLC) with known PD-L1 status.
  • You are age 18 or older
  • You are not pregnant.

Not eligible if:

  • Your have had prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields.
  • You who may become pregnant or who may impregnate a partner) unwilling to use highly effective contraceptives during therapy.
  • You are pregnant or unwilling to stop nursing

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Additional Study Information

Principal Investigator

Ashley Weiner
Lineberger Comprehensive Cancer Center

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Lung)

IRB Number

23-1739

ClinicalTrials.gov

NCT05624996

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