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Stage III Colon Cancer Study

This is a study for patients who have had surgery for stage III colon cancer. In this study we will use a test called circulating tumor DNA (ctDNA). Patients who have a negative result will be either observed or receive chemotherapy for 3 to 6 months. Patients who are positive will receive 6 months of standard chemotherapy or 6 months of a more intense treatment.

Age & Gender

18 years ~ 99 years
Male, Female

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

Screening for eligibility will include blood draws and a physical exam. Additional blood draws are needed throughout the study. Chemotherapy may or may not be required for 3-6 months. We will follow-up with you every 6 months for a total of 5 years.

In-person visits:
1-30

Total length of participation:
5 years

Looking for Specific Volunteers

Able to participate:

You have Stage IIIA or Stage IIIB colon adenocarcinoma
You have had a curative resection
You are willing to have multiple blood draws
You are willing to receive chemotherapy

Not eligible if:

You have metastatic cancer
You had a bowel perforation
You've had another cancer in the last 5 years
You have Gilbert's Syndrome
You have other uncontrolled illnesses or diseases

Contact the Team

Visit Location

Contact & Visit Location

Additional Study Information

Principal Investigator

Ranjit Joseph
UNC Hospitals - Rex

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Colorectal)

IRB Number

22-1388

ClinicalTrials.gov

NCT05174169

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