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A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

The purpose of this study to find out if enzalutamide, alone or combined with mifepristone, is effective in treating a specific type of breast cancer in comparison with standard chemotherapy with carboplatin, paclitaxel, capecitabine, or eribulin. The specific type of breast cancer include Triple-negative or ER/PgR-low and Androgen receptor positive breast cancer.

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

United States (Nationwide)

What will be asked of you

The study involves study drug infusions or dosing, physical exams, Electrocardiogram (ECG) (if needed), CT or MRI scans, Brain MRI or CT (If needed), routine and research blood tests, collection of tumor tissue, biopsy (if needed), questionnaires.

In-person visits:
5-20

Phone or online visits:
1-5

Total length of participation:
2-5 years

Looking for Specific Volunteers

Able to participate:

You have advanced or metastatic breast cancer not amenable to local therapy
You have been told you have Triple-negative or ER/PgR-low breast cancer
You have Androgen receptor positive breast cancer
You do not have another cancer that requires treatment
You have the ability to swallow oral medications

Not eligible if:

You have a history of brain metastases
You are pregnant or breast feeding
You had more than one prior chemotherapy for your metastatic breast cancer
You had prior enzalutamide therapy
You are on long-term or concurrent use of corticosteroid therapy

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Lineberger Clinical Research
cancerclinicaltrials@med.unc.edu
(919) 966-4432

Primary Visit Location

NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Yara Abdou
LCCC - Clinical Trials

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Breast)

IRB Number

24-0602

ClinicalTrials.gov

NCT06099769

Copyright © 2013-2022 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH. This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.

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Questions?

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