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Study on Hormones and Mood in Women with Depression

In this study, we want to see how changes in hormones during the menstrual cycle affect how women with Major Depressive Disorder feel.

Age & Gender

18 years ~ 45 years
Female

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

You will be asked to rate your mood daily over the course of 5 menstrual cycles. During two of those cycles, you will take active hormones (estrogen+progesterone) and placebo (you will get both, but at different times). You will also collect urine samples at home, and will complete 5 in-person lab visits during which we will assess brain activity using EEG.

Incentives

Up to $535

In-person visits:
6

Phone or online visits:
Up to 140 (daily ratings on your smartphone)

Total length of participation:
5 months

Looking for Specific Volunteers

Able to participate:

You are a female with Major Depressive Disorder
Your symptoms fluctuate with your menstrual cycle
You are medically healthy

Not eligible if:

You have a personal or family history of cancer or clotting disorders
You are using hormonal birth control
You are a smoker
You have a history of mania, psychosis, or substance use disorder; active suicidal ideation or an attempt within the last 5 years
You are pregnant or breastfeeding

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Chris Sikes-Keilp
chris_sikes-keilp@med.unc.edu

Primary Visit Location

Additional Study Information

Principal Investigator

Christopher Sikes-Keilp
Psychiatry

Study Type

Clinical or Medical
Interventional

Study Topics

Behavior
Glands and Hormones
Mental and Emotional Health
Sexual and/or Reproductive Health
Women's Health

IRB Number

24-1715

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