Study Details

Open

Severe Aplastic Anemia Treatment Study

In this study, we want to see if people with previously untreated Severe Aplastic Anemia (SAA) can be treated with marrow transplant from a donor that is not related.

Age & Gender

18 years ~ 75 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

You will need to have several tests done to see if you can be in the study and have a bone marrow transplant. These test include physical exam, blood tests, heart and lung tests, and bone marrow tests. If you are eligible for the study, you will receive chemotherapy before you receive your transplant. You will also receive 1 dose of radiation. On the day of transplant, you will receive donor cells through an IV infusion. Your doctor may give you medicine throughout your treatment to prevent side effects. After your transplant, you will need several tests to see how your body is doing with treatment, including exams, blood tests, and marrow tests. You will be asked to complete questionnaires at certain times. You will follow up with your doctor for 1 year after your transplant.

Incentives

You will be reimbursed $20.00 for each complete survey during this study

In-person visits:
18, including time in hospital prior to treatment and after treatment

Phone or online visits:
4; potential to complete surveys on paper, online or over the phone

Total length of participation:
1 year after transplant

Looking for Specific Volunteers

Able to participate:

You have a confirmed diagnosis of Severe Aplastic Anemia
you don't have a suitable fully matched related donor
you have adequate organ function as described in protocol
you agree to practice 2 effective methods of contraception or agree to abstinence

Not eligible if:

you have had prior treatment for Severe Aplastic Anemia
you have inherited bone marrow failure syndromes, such as Fanconi anemia and short telomere syndromes
Have formal diagnosis of Myelodysplastic syndrome
Prior allogeneic stem cell transplant or organ transplant
you have had Previous cancers, except for resected basal cell carcinoma or treated cervical carcinoma

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Janell Markey
janell_markey@med.unc.edu

Primary Visit Location

NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

William Wood
Lineberger Comprehensive Cancer Center

Study Type

Clinical or Medical
Interventional

Study Topics

Blood Conditions

IRB Number

24-1729

ClinicalTrials.gov

NCT06517641