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Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy with Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)

To investigate the rate of moderate-marked adverse effects in the breast and chest wall for patients with early-stage breast cancer or Ductal Carcinoma in Situ (DCIS) receiving five-fraction whole breast radiation therapy with concurrent boost as measureing radiation-specific toxicity.

Age & Gender

50 years ~ 99 years
Female

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

Radiation treatment will be done every other day (excluding weekends) for a total of 5 treatments. After treatment follow-up with go up to 2 years. During these follow-up visits, the study team will review any side effects you might be experiencing and ask you to complete questionnaires regarding your health. The study team may also access your medical records to review your medical history and follow your progress for up to 3 years after your 24-month visit.

In-person visits:
10-15

Total length of participation:
2 years on study and 3 years medical record abstraction, 5 years total

Looking for Specific Volunteers

Able to participate:

You are a woman 50 years or older
You have received breast conserving surgery
You plan to receive whole breast 3D conformal or whole breast intensity modulated radiation therapy with standard dose tumor bed boost

Not eligible if:

You have received concurrent breast reduction involving tissue rearrangement in the lumpectomy cavity
You have synchronous bilateral breast cancer requiring bilateral radiation therapy
You have clinical or imaging evidence of distant metastases
You have received ipsilateral breast or thoracic radiation

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Dana Casey
Lineberger Comprehensive Cancer Center

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Breast)
Women's Health

IRB Number

24-2001

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