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Immune Functioning and Social Reward Processing in Autism and Typical Development

The purpose of this study is to investigate relations between (i) neural responses to social rewards, measured via electroencephalography (EEG), (ii) a blood-derived composite marker of systemic inflammation, and (iii) ASD symptoms and quality of life. This project will provide a deeper understanding of relations between neural responses to social rewards, immune functioning, and symptom expression in ASD and has the potential to contribute to the development of EEG-based measures that may be suitable endpoints in future mechanistic trials investigating novel ASD interventions targeting inflammatory processes.

Age & Gender

  • 18 years ~ 29 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Extended hours (M-F, early morning or evening)
  • Weekend hours, if needed

Location

North Carolina (Statewide)

What will be asked of you

As part of your clinical characterization visit, you will complete a brief cognitive evaluation (and autistic participants will also complete an autism evaluation). This will be followed by an EEG recording session at the Carolina Institute for Developmental Disabilities and a blood draw appointment at the UNC Clinical and Translational Research Center. Other study tasks include responding to questionnaires and participating in a social approach task.

Incentives

Up to $150

In-person visits:
1-2
Total length of participation:
1-2 in-person assessments, lasting approximately 1 week

Looking for Specific Volunteers

Able to participate:

  • You have a diagnosis of autism spectrum disorder
  • You are between 18 and 29 years old

Not eligible if:

  • You have a neurological condition (e.g. seizures or TBI)
  • ou have sever seasonal allergies or a disorder/disease that influences inflammation (e.g. an autoimmune condition, cancer, HIV)

Looking for Healthy Volunteers

Requirements for healthy volunteers are different than for those with a specific condition. If you are interested in becoming a healthy volunteer for this study, use the below categories to determine if you are able to participate.

Able to participate:

  • You do not have a history of an autism spectrum or other psychiatric/neurodevelopmental diagnosis
  • You are between 18 and 29 years old

Not eligible if:

  • You have a neurological condition (e.g. seizures or TBI)
  • You have sever seasonal allergies or a disorder/disease that influences inflammation (e.g. an autoimmune condition, cancer, HIV)
  • You have a genetic syndrome associated with ASD, such as Fragile X.

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Secondary Visit Location

Carolina Institute for Developmental Disabilities
101 Renee Lynne Ct, Carrboro, NC 27510, USA

Additional Study Information

Principal Investigator

Gabriel Dichter
Psychology and Neuroscience

Study Type

Behavioral or Social
Observational

Study Topics

Brain, Head, Nervous System
Healthy Volunteer or General Population
Immune System/Infections
Mental and Emotional Health
UNC or UNC Health employees
UNC Students (undergrad, grad, professional)

IRB Number

22-1767

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Copyright © 2013-2022 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH.  This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.

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