The purpose of this study is to investigate whether five days of personalized non-invasive brain stimulation can improve depression in people aged 18-70 who have been diagnosed with major depressive disorder.
After a brief online pre-screening, we will confirm your eligibility in a remote screening appointment (approximately 1 hour). Here, we will ask you questions about your medical history and mental health. Participants can decide whether they would like to opt in to a 15 minute MRI (one hour total for session; optional extra to the main study), conducted at the Biomedical Research Imaging Center or BRIC. You will then attend the Carolina Center for Neurostimulation for five consecutive days of non-invasive brain stimulation and some assessments about your mental health. These sessions are scheduled around your availability on a Monday to Friday. You will also have electroencephalography (EEG) on the Monday and the Friday to measure changes in your brain activity. There will be one in-person follow-up visit two weeks following the last stimulation which will involve clinical assessments and EEG. Day 1 and Day 5 will take approximately 3-3.5 hours to complete, and Days 2-4 and the follow-up will take approximately 1.5 hours to complete.
Up to $430
Carolina Center for Neurostimulation
100 Market Street, Chapel Hill, NC, USA
David Rubinow
Psychiatry - Research
Clinical or Medical
Interventional
Behavior
Brain, Head, Nervous System
LGBTQIA+
Mental and Emotional Health
UNC or UNC Health employees
UNC Students (undergrad, grad, professional)
24-2166