For the first 3 months, you will have 7 visits with a study clinician. These visits will be every two weeks. During each visit, the clinician will help adjust your medication, monitor your progress, ensure your safety, and answer any questions you may have. You will also complete questionnaires similar to the ones you filled out at the beginning of the study. Throughout this time, you will take one of the 4 medications approved to treat bipolar depression. If you don't feel better after the first 3 months, you'll have the option to switch to a different medication to see if it works better for you. After the first 3 months, you will have 5 additional visits. Every 8 weeks, you'll complete similar assessments until the study ends.