Open

Trial of Inhaled Ensifentrine for Bronchiectasis

This study aims to find out if inhaled Ensifentrine works well as a treatment for moderate to severe bronchiectasis. We will also check how safe the medication is and how well people can handle it.

Age & Gender

18 years ~ 85 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

Come to in-person visits where we will: Check your vital signs. Take a blood sample. Have a physical exam by the study doctor. Fill out some questionnaires. Get refills of your study medication to use at home. Some visits will also include: Breathing tests. Collection of sputum (mucus) for testing. CT Scans of your Lungs/Chest

Incentives

Study medication and routine testing/monitoring

In-person visits:
7-20

Phone or online visits:
1

Total length of participation:
7 months to 3 years

Looking for Specific Volunteers

Able to participate:

Are between the ages of 18 and 85
Have a diagnosis for bronchiectasis and have received antibiotics or been in the hospital for your condition in the last year
Regularly produce sputum (mucus) while coughing
Willing/able to travel to UNC-Eastowne medical center for study visits

Not eligible if:

Have a diagnosis of COPD
you are a current smoker
A diagnosis of primary ciliary dyskinesia or cystic fibrosis
have a history of cancer (treated or untreated) in the last 5 years except for skin cancer
are a current UNC student or employee

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Kenneth Olivier
Medicine-Pulmonary

Study Type

Clinical or Medical
Interventional

Study Topics

Chronic Conditions
Immune System/Infections
Lungs and Breathing

IRB Number

24-2873

ClinicalTrials.gov

NCT06559150

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