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Mycobacterial Lung Infection Treatment Study

In this study, we want to find out how safe inhaled Clofazimine is and how well it works for adult patients with mycobacterial lung infections. We hope that this medicine will work just as well or even better than other forms of the drug. We also hope it will cause fewer side effects for patients.

Age & Gender

  • 18 years ~ 85 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

At each in person visit, you will have testing completed (vital signs, blood work, urine, breathing testing, ECG, sputum collection), meet with one of the study doctors, and complete a set of questionnaires. At home, you will be required to take the study medication as instructed until your participation is complete.

Incentives

Up to $4,100, Study medication and routine labwork/testing

In-person visits:
9-15
Phone or online visits:
2-4
Total length of participation:
7 to 25 months

Looking for Specific Volunteers

Able to participate:

  • You have been diagnosed with a pulmonary M. Avium Complex infection
  • You are currently receiving treatment for your M. Avium Complex Pulmonary Infection
  • You are able to cough up sputum (mucus)

Not eligible if:

  • You have a diagnosis of Cystic Fibrosis or Tuberculosis
  • You are currently pregnant/breastfeeding or may become pregnant
  • You currently have lung cancer or any cancer that required treatment within the last 3 years
  • You have a family history of sudden cardiac death

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Leigh Anne Daniels
Medicine-Pulmonary

Study Type

Clinical or Medical
Interventional

Study Topics

Immune System/Infections
Lungs and Breathing

IRB Number

24-3060

ClinicalTrials.gov

NCT06418711

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