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APVO436-5201: APVO436 Phase 1b/2 Study in Patients with Newly Diagnosed acute myeloid leukemia (AML).

We are looking for a dose of the APVO436 in combination with venetoclax and azacitidine that can be administered safely to participants who have been diagnosed with AML.

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

North Carolina (Statewide)

What will be asked of you

Depending on the visit, you will meet with a study team member to go through a variety of tests such as a physical examination, pregnancy test, patient diary, ECG, Urinalysis, bone marrow, questionnaires, and medication compliance assessments.

In-person visits:
10-15

Total length of participation:
you will remain on study treatment until you experience unacceptable side effects, your disease progresses, you withdraw consent, or you meet any other withdrawal criteria.

Looking for Specific Volunteers

Able to participate:

You have Acute Myeloid Leukemia (AML)
You are over the age of 18
You are not pregnant

Not eligible if:

You have any other type of cancer
You are on another clinical treatment trial
You are pregnant

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Lineberger Clinical Research
cancerclinicaltrials@med.unc.edu
(919) 966-4432

Primary Visit Location

Lineberger Comprehensive Cancer Center
NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Joshua Zeidner
Medicine-Hematology

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Leukemia)

IRB Number

24-3173

ClinicalTrials.gov

NCT06634394

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