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Dendritic Cell Immunotherapy for Treatment of Adult GBM

The purpose of this research is to see if an experimental vaccine, which is created from your tumor tissue and dendritic cells isolated from your blood, can be an effective therapy when given after your standard treatment of surgery, chemotherapy, and radiation.

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

United States (Nationwide)

What will be asked of you

If you decide to take part in this research study, the general procedures include taking a sample of your tumor tissue and creating a vaccine with help of your dendritic cells isolated from your blood, (if you are in the group receiving the vaccine). You will have several exams and tests before and during the study.

In-person visits:
21

Total length of participation:
5 years

Looking for Specific Volunteers

Able to participate:

Presumed diagnosis of GBM deemed to be potentially resectable and deemed to be a good candidate for postoperative standard of care temozolomide and radiation therapy.
Ability to receive injections.
Adequate kidney, liver, bone marrow function, and immune function.

Not eligible if:

Patients who are pregnant or breastfeeding.
Known active HIV or hepatitis infection.
Any severe or uncontrolled medical condition that could affect participation in this study as determined by the investigator, for example severe cardiac disease.
Treatment with another investigational drug or other experimental intervention within the last 30 days.

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Lineberger Clinical Research
cancerclinicaltrials@med.unc.edu
(919) 966-4432

Primary Visit Location

Lineberger Comprehensive Cancer Center
NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Dominique Higgins
LCCC - Clinical Trials

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Brain and Other Nervous System)

IRB Number

25-0536

ClinicalTrials.gov

NCT06805305

Copyright © 2013-2022 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH. This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.

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Questions?

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