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A Low-Dose Tamoxifen Trial for Early Breast Cancer

This study wants to see if taking a low dose of tamoxifen works as well as the usual hormone therapy for breast cancer. The doctors will check if low-dose tamoxifen can stop breast cancer from coming back, just like usual hormone treatments, but with fewer side effects.

Age & Gender

  • 18 years ~ 99 years
  • Female

Visit Availability

  • Standard business hours (M-F, 8-5)

Location

United States (Nationwide)

What will be asked of you

This study will include taking blood samples, checking your vital signs, doing physical exams, and performing assessments. You will also have a mammogram or MRI, a tumor biopsy, and an EKG. We will look at any side effects and how you respond to the study medicine.

Total length of participation:
15 years

Looking for Specific Volunteers

Able to participate:

  • You are Postmenopausal
  • You have been diagnosed with unilateral invasive breast adenocarcinoma
  • You have not received prior treatment for your breast cancer
  • 18 years and female

Not eligible if:

  • You have experienced Abnormal or dysfunctional uterine bleeding within 1 year
  • You have a history of breast or thoracic radiotherapy for any previous condition
  • You have history of ipsilateral invasive breast cancer
  • You have metastatic breast cancer

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Secondary Visit Location

UNC Hospitals Hillsborough Campus
460 Waterstone Dr, Hillsborough, NC 27278, USA

Additional Study Information

Principal Investigator

Lisa Carey
Lineberger Comprehensive Cancer Center

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Breast)
Women's Health

IRB Number

25-0585

ClinicalTrials.gov

NCT06671912

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