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Type 2 Diabetes Weight Loss Study

To evaluate the effect of a new combination of medications on body weight and body fat mass in people with type 2 diabetes and overweight/obesity.

Age & Gender

18 years ~ 75 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

At each visit, you will meet with a member of the study team and answer questions about your health. You will be asked to complete diaries, answer questionnaires, measure your blood sugar at home, work with a registered dietitian, and follow the instructions of the study doctor. The study also involves fasting blood draws, EKGs, MRIs, DEXA scans, bioimpedance analysis, grip strength tests, 12-step stair climb tests, wearing an activity tracker, and willingness to inject yourself with the study medications weekly.

Incentives

Information provided upon request, study medicine, working with a registered dietitian

In-person visits:
13

Phone or online visits:
2

Total length of participation:
About 14 months

Looking for Specific Volunteers

Able to participate:

you have had type 2 diabetes for at least 6 months
your HbA1c is at least 7.5%
your diabetes is managed with diet and exercise alone or with metformin with or without an SGLT-2 inhibitor (ex: Farxiga, Jardiance, Invokana)
your BMI is at least 27 kg/m2
your body weight has been stable for the past 3 months

Not eligible if:

you have had weight loss surgery or procedure
you have type 1 diabetes, LADA, or have been hospitalized for diabetes in the past 6 months
you have taken any medications for diabetes or weight loss other than metformin or an SGLT-2 inhibitor in the last 3 months
you can't tell when your blood sugar is low
you are currently pregnant or breastfeeding, planning to get pregnant, or are unwilling to follow the study's contraceptive guidance

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Klara Klein
Medicine-Endocrinology

Study Type

Clinical or Medical
Interventional

Study Topics

Diabetes
Obesity

IRB Number

25-0792

ClinicalTrials.gov

NCT06901349

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Questions?

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