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Study for a new treatment for a type of blood cancer, Acute Myeloid Leukemia (AML)

Join our study for a new treatment for a type of blood cancer, Acute Myeloid Leukemia (AML) with a specific mutation called FLT3. We are looking for older adults who have recently been diagnosed and who may not be fit for intense treatments. The study involves testing a combination of medicines to see if they help. This study looks at two ways to treat AML. We will compare the usual treatment with Azacitidine and Venetoclax to adding a new medicine called Gilteritinib to them.

Age & Gender

  • 18 years ~ 60 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)

Location

United States (Nationwide)

What will be asked of you

You will have a check-up, heart test, blood tests, and a bone marrow test. You will also fill out some questionnaires.

In-person visits:
+20
Total length of participation:
+24 months

Looking for Specific Volunteers

Able to participate:

  • Adults greater than 18 years of age
  • Diagnosis of Acute Myeloid Leukemia (AML)
  • No prior treatment
  • Must have a FLT3-ITD or D835 mutation
  • Good heart function

Not eligible if:

  • Adult greater than 60 years of age
  • Poor liver function
  • Poor kidney function

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Breast Imaging Center
NC Women's Hospital
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Joshua Zeidner
Lineberger Comprehensive Cancer Center

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Leukemia)

IRB Number

25-0948

ClinicalTrials.gov

NCT06317649

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