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Resistant Hypertension Study

The purpose of this study is to see how prevalent high cortisol levels are in people with high blood pressure that is resistant to treatment.

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

You will be asked to answer questions about your health and medications, follow instructions from the study doctor for a dexamethasone suppression test, and potentially have a non-contrast CT scan done. This study involves a blood draw.

Incentives

Information provided upon request, Study results

In-person visits:
3

Total length of participation:
Anticipated to be less than 4 weeks

Looking for Specific Volunteers

Able to participate:

you take 3 or more antihypertensive medications at their maximally tolerated doses and your blood pressure is still above target
you take 4 or more antihypertensive medications and your blood pressure is at target or above target

Not eligible if:

you don't take your blood pressure medications as they are prescribed
you have white coat syndrome (high blood pressure only in the doctor's office)
you are currently pregnant or lactating, or are currently taking oral contraceptive pills and are unwilling to pause treatment for 6 weeks
you have severe untreated sleep apnea
you have Cushing syndrome or congential adreanl hyperplasia

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Biomedical Research Imaging Center
Marsico Hall (UNC-Chapel Hill)
125 Mason Farm Rd, Chapel Hill, NC 27514, USA

Secondary Visit Location

UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

John Buse
Medicine-Endocrinology

Study Type

Clinical or Medical
Observational

Study Topics

Blood Pressure

IRB Number

25-0980

ClinicalTrials.gov

NCT06829537

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Helpful Links

Questions?

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