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Study on Asthma Treatment

We are studying the safety of a new asthma medicine called AMG 691. We want to see how people handle the medicine when taking multiple doses. We need healthy people and people with mild-to-moderate asthma to join this study.

Age & Gender

18 years ~ 65 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

If you decide to join the study, we will do some tests to see if you qualify. If the tests show you don't qualify, you can't join the study, but the study doctor will talk with you about other choices and may refer you back to your own doctor. If the tests show you qualify and you join the study, you will be part of it for about 211 days. This includes up to 28 days to check if you can join, a time when you will get 2 or 3 doses of AMG 691 or a placebo on specific days, and a follow-up visit about 126 days after your last dose to check on your health.

Incentives

Earn up to $5000 if you complete all study visits. Get paid for each visit you finish.

In-person visits:
20

Total length of participation:
7 months

Looking for Specific Volunteers

Able to participate:

Documented diagnosis of asthma for ³ 12 months prior to screening visit.
Peripheral blood eosinophil count ³ 300 cells per mL at screening visit and day -1.

Not eligible if:

Any medical condition, other than asthma, requiring daily use of systemic corticosteroids or intermittent systemic corticosteroid bursts (ie, ³ 10 mg/day prednisone or equivalent for
Asthma symptoms or exacerbation requiring 2 or more systemic corticosteroid bursts (ie, ³ 10 mg/day prednisone or equivalent for ³ 3 days each) in the

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

David Peden
Center for Environmental Medicine Asthma and Lung Biology (CEMALB)

Study Type

Clinical or Medical
Interventional

Study Topics

Lungs and Breathing

IRB Number

25-1000

ClinicalTrials.gov

NCT06637371

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Questions?

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