Study Details

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Alopecia Areata Study

The purpose of the study is to learn about the safety and effects of the study medicine (called ritlecitinib) for the treatment of alopecia areata. Alopecia areata is a disease that causes hair loss on the scalp, face, and areas of the body. Ritlecitinib is approved in many countries at a dose of 50 mg (milligram) taken by mouth once a day for the treatment of patients 12 years and older with severe alopecia areata. This study will look at both the 50 mg dose and a 100 mg dose.

Age & Gender

12 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

At each visit, you will meet with a member of the study team and fill out questionnaires. The study also involves vital signs, blood draws, urine testing, physical exams, ECG, Chest x-ray, audiology assessments, willingness to provide medical history and use of medications, use of birth control method if applicable, and willingness to take the study medication as directed.

Incentives

Information provided upon request

In-person visits:
8

Phone or online visits:
1

Total length of participation:
12 months

Looking for Specific Volunteers

Able to participate:

You have been diagnosed with alopecia areata.
You have greater than or equal to 50% scalp hair loss.
You are age 12 and up.

Not eligible if:

You have a history of cancer.
You have other causes for your hair loss besides alopecia areata (including androgenetic alopecia)
Your current episode of hair loss has lasted greater than 10 years.
You have a history of certain viral infections
You are unwilling to avoid live vaccines during the study.

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Secondary Visit Location

Dermatology Clinical Trials Unit (DCTU)
UNC Dermatology and Skin Cancer Center at Southern Village
410 Market St Ste 362, Chapel Hill, NC 27516, USA

Additional Study Information

Principal Investigator

Donna Culton
Dermatology-Research

Study Type

Clinical or Medical
Interventional

Study Topics

Skin, Hair, and Nails

IRB Number

25-0411

ClinicalTrials.gov

NCT06873945