During screening, the following procedures will be performed: medical/oncology history, adverse event assessment, current and previous medications, performance status, electrocardiogram, physical examination and vital signs, blood and urine collection, viral serologies, pregnancy test (for women of child-bearing potential), bone marrow aspirate, bone marrow core biopsy, BCL2 and t(11;14) central testing, skeletal survey, plasmacytoma evaluation, and tumor lysis syndrome (TLS) prophylaxis. In addition to the procedures described above, the following procedures will be performed during study cycles: biomarker research, pharmacokinetic (PK) testing, response assessment, infection prophylaxis, study diary, study drug dispensation, post-treatment follow-up visits, and survival follow-up visits.