Open

JZP598-303

The purpose is to compare the efficacy of zanidatamab plus chemotherapy versus trastuzumab plus chemotherapy

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

North Carolina (Statewide)

What will be asked of you

you will have tests done several times during the study. The study doctor will monitor both your cancer and your overall health. The study consists of a screening and randomization visit , study treatment , end of study treatment, long term follow up, lab test and sample collection. You will be asked to fill out questionnaires

Incentives

Total length of participation:
up to 3 years

Looking for Specific Volunteers

Able to participate:

if you have histologically confirmed HER2-positive breast cancer
if you have measurable disease
if you are eligible to receive one of the chemotherapy options listed in the physician's choice of chemotherapy
If you are capable of giving signed informed consent
if you have adequate hematologic parameters as defined in the protocol.

Not eligible if:

if you have known or suspected leptomeningeal disease..
if you have uncontrolled or significant cardiovascular disease.
if you have known HIV infection.
if you have active hepatitis B or C infection.
if you have any condition that would prevent treatment with the physician's choice of chemotherapy

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Lineberger Comprehensive Cancer Center
cancerclinicaltrials@med.unc.edu
(919) 966-4432

Primary Visit Location

Lineberger Comprehensive Cancer Center
NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Secondary Visit Location

UNC Hospitals Hillsborough Campus
460 Waterstone Dr, Hillsborough, NC 27278, USA

Additional Study Information

Principal Investigator

Claire Dees
LCCC - Clinical Trials

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Breast)
Women's Health

IRB Number

25-1169

ClinicalTrials.gov

NCT06435429

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Helpful Links

Questions?

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