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Study on Radiation Treatment for Pancreatic Cancer

We are looking for volunteers to join a study about a new cancer treatment. If you have advanced pancreatic cancer and have already had 4-6 months of chemotherapy, you may be able to participate. We're testing if high-dose radiation therapy works better than usual care. Usual care means either more chemotherapy, standard lower-dose radiation, or just watching and waiting. These treatments can slow down the cancer but might not help people live longer. Radiation therapy uses strong X-rays to kill cancer cells and make tumors smaller. We're studying whether giving higher doses of radiation in a precise way can help people with this kind of cancer live longer. By joining, you can help find new ways to treat pancreatic cancer. Your participation could make a difference for you and others in the future.

Age & Gender

  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

We're inviting you to be part of important research. In this study, you'll be randomly placed into one of two groups. Here's what being in the study means: - Every 3 months for the first 2 years, and then once a year for the next 3 years, you'll have a CT or MRI scan. - You'll receive treatment and answer some questions about how you're feeling. - We will also check for any side effects from the treatment. - You might be asked to give blood samples and have a small piece of tumor tissue taken for testing. We appreciate your interest and look forward to your valuable contribution!

In-person visits:
11
Phone or online visits:
11
Total length of participation:
60 months

Looking for Specific Volunteers

Able to participate:

  • Must have received 4-6 months of active chemotherapy with FOLFIRINOX (8-12 cycles) or NALIRIFOX (8-12 cycles) or gemcitabine/Nab-Paclitaxel (4-6 cycles) (1 regimen, no sequential chemotherapy).
  • Age ≥ 18 years
  • Pathological proven diagnosis of pancreatic ductal adenocarcinoma
  • No active duodenal or gastric ulcers
  • Not pregnant and not nursing

Not eligible if:

  • No proven diagnosis of pancreatic ductal adenocarcinoma
  • HIV-positive and receiving anti-retroviral therapy with undetectable viral load
  • Pregnant and/or nursing

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Theodore Yanagihara
Lineberger Comprehensive Cancer Center

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Pancreatic)

IRB Number

25-1644

ClinicalTrials.gov

NCT06958328

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