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Acetaminophen Versus Ibuprofen for Discomfort in Crohn's Disease

We are doing a small study to help plan a bigger study in the future. We want to see how two common pain medicines-ibuprofen and acetaminophen-work and how safe they are for treating period cramps in people with Crohn's disease. The information we learn now will help us run a better, bigger study later.

Age & Gender

18 years ~ 44 years
Female

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

North Carolina (Statewide)

What will be asked of you

If you join, you will come for one in-person visit. After that, you can do the rest of the study from home. You will take the study medicine during your period cramps, give small stool samples, and fill out short surveys.

Incentives

up to $575 for participation

In-person visits:
1

Phone or online visits:
9 surveys per menstrual cycle, a midpoint check in, and an end of study interview

Total length of participation:
4-6 months

Looking for Specific Volunteers

Able to participate:

Crohn's disease
have painful periods
have regular menstrual cycles

Not eligible if:

Have any of the following: endometriosis, adenomyosis, polycystic ovarian syndrome, endometrial fibroids/polyps, chronic pelvic inflammatory disease, a history of pelvic surgery, any other pelvic conditions
Are pregnant or plan to become pregnant during the study period
Have made changes to your birth control in the last three months or plan to do so during the study period
Take hormone therapy including estrogen or progesterone that is not part a contraceptive (birth control) method
Have an allergy to ibuprofen or acetaminophen

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Secondary Visit Location

Clinical Research Unit
UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Erica Brenner
Pediatrics - Gastroenterology

Study Type

Clinical or Medical
Interventional

Study Topics

Stomach, Digestion and Gut Health

IRB Number

24-2940

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Questions?

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