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Sparing Parotid Ducts via MRI Sialography for Reduced Patient-Reported Xerostomia

Radiation treatment for head and neck cancer can often cause a very dry mouth. This dryness can last for a long time, even after the treatment ends. In our study, we want to see if changing where the radiation is aimed can help with this dryness. If you join, you'll fill out some simple questionnaires and give saliva samples. We'll also check in with you for about a year after your treatment to see how you're doing.

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

North Carolina (Statewide)

What will be asked of you

A total of 5 research visits will align with your standard of care appointments where you will have scans, labs, and a physical exam as scheduled by your doctor. In addition to these assessments you will complete questionnaires, provide a saliva sample, and have a MRI scan for research purposes.

Incentives

We will cover the cost for any trial-related scans you need.

In-person visits:
5

Total length of participation:
10-18 months (dependent on treatment prescription/duration and follow-up date variability)

Looking for Specific Volunteers

Able to participate:

Current diagnosis of oropharynx cancer, graded at T0-4, N0-3, M0 (AJCC 8th edition)
Male or female, aged ≥ 18 years at the time of consent
No contraindications to receiving MRI such as: implanted electrical devices, pregnancy, and significant quantities of metal in the head/neck

Not eligible if:

Patients with Sjogren's disease or baseline xerostomia (CTCAE > 0 for dry mouth)
Patients with lesions involving the salivary glands on diagnostic imaging
Patients with an allergy to lemon juice
Prior lifetime history of radiation therapy to the head and neck
Current pregnancy or lactation

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Lineberger Clinical Research
cancerclinicaltrials@med.unc.edu
(919) 966-4432

Primary Visit Location

UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

David Fried
LCCC - Clinical Trials

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Head and Neck)
Ear, Nose, and Throat

IRB Number

25-2024

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