The purpose of this study is to see how a new creatine supplement, called OptiCreatine, affects the amount of creatine in the blood, digestion, and body fluid balance compared to regular creatine monohydrate. Creatine is a natural substance that helps muscles work better during short bursts of high-intensity exercise. Regular creatine works well for most people, but some experience stomach discomfort or have trouble absorbing it. OptiCreatine combines creatine with other ingredients that may help the body absorb it more easily and reduce digestive issues. In this study, healthy men and women will take either OptiCreatine or regular creatine for short periods while researchers measure creatine levels in the blood, track digestive symptoms, and monitor hydration. This research may help athletes, active individuals, and healthcare providers choose creatine products that work best with fewer side effects.
Before the first visit, consent will be obtained and a health history questionnaire will be completed. At visit one of the acute phase, height, weight, and BMI will be measured, and a urine sample will be collected to check hydration. Participants will complete gastrointestinal (GI) symptom questionnaires. In the acute phase, body composition will be measured to assess fluid distribution. A fasting blood sample will be collected before supplement ingestion. Participants will consume a single dose (5 g) of either OptiCreatine or creatine monohydrate, mixed in water, in opaque containers. Blood samples will be collected at multiple timepoints over 5 hours to measure creatine levels. GI questionnaires and body composition will be repeated. Participants will return 3 days later for their 2nd visit where measures will be repeated with the opposite treatment. If opting in for the chronic phase testing, this can serve as pre-loading phase measures. After a 5 day loading phase, participants will return for GI questionnaires, body composition and anthropometrics.
Up to $300 for completion of acute, and chronic arms, Body Composition Results
Requirements for healthy volunteers are different than for those with a specific condition. If you are interested in becoming a healthy volunteer for this study, use the below categories to determine if you are able to participate.
Fetzer Hall (UNC-Chapel Hill)
210 South Rd, Chapel Hill, NC 27514, USA
Abbie Smith-Ryan
Exercise and Sport Science
Clinical or Medical
Interventional
Healthy Volunteer or General Population
25-2072
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