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Menopause Transition Study

The purpose of the study is to better understand the links between the menopause transition, cardiovascular disease, metabolic syndrome, and aging.

Age & Gender

45 years ~ 55 years
Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

North Carolina (Statewide)

What will be asked of you

The protocol will require baseline, 12 month and 24 month assessments. They will have blood sampling for collection of study primary and secondary endpoints and a physical examination with biometric measurements. Flow mediated dilation will be performed at baseline, 12 and 24 months.

Incentives

Information provided upon request, Participants will be able to keep any activity trackers or blood pressure cuffs that are required for participation in the study.

In-person visits:
3

Phone or online visits:
2

Total length of participation:
2 years

Looking for Specific Volunteers

Able to participate:

Late menopause transition (greater than 60 but less than 365 days of amenorrhea)
No current use of hormone therapy or hormonal contraception
Presence of uterus and at least one ovary
Have a smartphone and broadband access adequate to attent telehealth appointments

Not eligible if:

Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia with a BMI > 30
Lack regular menstrual periods in mid-reproductive life (ages 25-38) when not on hormones or not pregnant
Pregnancy or actively trying to get pregnant
Undiagnosed abnormal uterine bleeding
Untreated alcoholism or substance use

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

The UNC Family Medicine Center (UNC-Chapel Hill, Aycock Building)
590 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Genevieve Neal-Perry
Obstetrics and Gynecology - Administration

Study Type

Clinical or Medical
Observational

Study Topics

Aging
Diabetes
Eating, Nutrition, and Metabolism
Heart and Circulation
Obesity
Women's Health

IRB Number

25-2597

ClinicalTrials.gov

NCT06975111

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