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Study on hereditary transthyretin amyloidosis (hATTR) with polyneuropathy.

This study will test the safety of a drug called nucresiran and will find out what effects, if any, nucresiran has on people with hereditary transthyretin amyloidosis (hATTR) with polyneuropathy.

Age & Gender

  • 18 years ~ 85 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)

Location

District of Columbia (Washington DC), Florida, Georgia, North Carolina, South Carolina, Tennessee, Virginia, West Virginia

What will be asked of you

Generally, you will go to the study site where you will meet with your study team. They will ask how you have been and perform standard tests that include: ·Asking about your health and any medications or supplements you take. ·Collecting blood and urine samples ·Study drug administration ·Checking your vital signs (like blood pressure, heart rate, respiratory rate, temperature, and weight) ·Neurological exams ·Physical exams ·Questionnaires ·Heart monitoring tests ( electrocardiograms [ECGs], echocardiograms [ECHOs])

Incentives

In-person visits:
23
Total length of participation:
Up to 3 years

Looking for Specific Volunteers

Able to participate:

  • have hereditary transthyretin amyloidosis (hATTR) with polyneuropathy
  • are 18 to 85years old

Not eligible if:

  • have had a liver transplant
  • have type I diabetes
  • are pregnant or breastfeeding

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Rebecca Traub
Neurology-Neuromuscular

Study Type

Clinical or Medical
Interventional

Study Topics

Brain, Head, Nervous System
Chronic Conditions
Genetics and Genetic Disorders

IRB Number

25-2866

ClinicalTrials.gov

NCT07223203

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