The purpose of this study is to identify and genomically-characterize individuals with genetically unexplained neurodevelopmental disorders, such as epilepsy. The overarching goal is to provide patients with improved information about the underlying genetic basis of their disorder and illuminate novel genetically-defined treatment approaches in the future.

The purpose of the study is to identify certain processes following brain injury that may be associated with the risk of developing epilepsy.

In this research study we want to learn more about resting state brain networks in patients with Tuberous Sclerosis Complex (TSC). Specifically, we want to know how resting state brain networks can guide surgical planning and improve seizure outcomes.

we want to learn more about seizure activity while a patient with epilepsy is not seizing or is at "rest" using data from resting state intracranial EEG (rs-iEEG) and resting state functional MRI (rs-fMRI).

We want to assess If the abnormal network patterns seen in seizure networks of epilepsy have similar implications when observed in patients with severe acute brain injury and therefore are modulated by antiseizure medication (ASM). If those networks respond to the ASM, then they may have a relationship with epileptogenic brain activity in this clinical context too and therefore could benefit from ASM even though they do not present ictal activity on their EEG.