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UNC-Chapel Hill Department of Neurology

27 studies match your search
Open

Theatre Program Intervention for People with Parkinson's disease assessing vocal function, mood, and quality of life

No experience necessary! Be part of our theater group which utilizes movement, acting, improv, speech therapy and other approaches to improve quality of life for those living with Parkinson's disease and their carepartners! Participate in 8 sessions to enhance your theatrical skills and knowledge. You will then participate in a live performance. Experience the magic of live theater and be a part of this vibrant community event. You may be able to participate in a research study that assesses improvement in voice function, mood, and quality of life for people with Parkinson's Disease. Participating in the study is not required to participate in the program.

Age & Gender
  • 35 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Aging
  • Brain, Head, Nervous System
Visit Location
Open

Placebo controlled Phase 3 Trial of Descartes-08 in pateints with generalized Myasthenia Gravis

Most patients with generalized Myasthenia Gravis need treatments that carry substantial risk of side effects and toxicity, Descartes-08 is a cell therapy is a RNA based CAR-T that causes direct killing of target cells without serious generalized toxicities.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
Open

ARGX-117-2302- Phase 3, Randomized, Double-Blind study to evaluate effectiveness and safety of empasiprubart versus IVIg in patients with multifocal motor neuropathy

This study aims to evaluate the effectand safety of empasiprubart compared with intravenous immunoglobulin (IVIg) treatment in adults with multifocal motor neuropathy (MMN). This study will also check how empasiprubart affects the body, how it is absorbed and removed from the body, and how the immune system reacts to empasiprubart.

Age & Gender
  • 18 years ~ 99 years
  • Male, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
Open

A Randomized, Double-Blinded, Placebo-Controlled, Phase 3, Study in Adult Participants With Ocular Myasthenia Gravi

The aim of this study is to measure the efficacy (how well it works) and safety of efgartigimod compared with placebo (inactive substance) in participants with ocular myasthenia gravis (oMG). The study will also measure the long-term efficacy, safety, and tolerability of efgartigimod.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
Not currently enrolling

Parkinson's Disease Treatment study

In this study, we are trying to find out how safe and helpful a new drug is when it is put directly into the brain during surgery. This drug is used to help with the movement problems caused by Parkinson's disease.

Age & Gender
  • 45 years ~ 75 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
Visit Location
Open

The ADD-Me Roster: a registry for those interested in brain health or Alzheimer's research

Do you have problems with your thinking or memory? Or a parent or sibling with dementia? If so, we'd like you to join this registry about the brain and Alzheimer's disease. In return for providing us with a little bit of your health history and background, we will connect you with researchers doing studies you can join, without obligation. Many studies pay a stipend and some offer a possible treatment.

Age & Gender
  • 45 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Aging
  • Brain, Head, Nervous System
  • Healthy Volunteer or General Population
Visit Location
100% Remote (online, phone, text)
Open

ARGX-113-2308

Efgartigimod has been approved by the U.S. FDA (Food and Drug Administration) as a treatment for adult patients with gMG in whom AChR-Ab's are present. However, it was not approved it for the form of gMG that is AChR Ab seronegative (antibodies not present). and therefore this study is now testing how efragtigimod works in patients without any antibodies,

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
Open

A randomized open label trial examining the effectiveness of Ofatumumab versus current therapy on relapsing multiple sclerosis.

Are you between 18 and 45 years of age and diagnosed with multiple sclerosis, without MS relapses within the past year? Are you currently prescribed with MS medication? If so, you may be able to participate in a research study examining whether a switch to a high-efficacy medication- Ofatumumab, would work better for you than your current treatment.

Age & Gender
  • 18 years ~ 45 years
  • Male, Female, Gender Inclusive
Study Interest
  • Chronic Conditions
  • Immune System/Infections
Open

Parkinson's Disease Genetic Registry

Have you or a family member been diagnosed with Parkinson's Disease? Would you be interested in helping researchers learn more about Parkinson's by giving a blood or saliva sample? If so, you may be eligible to participate in a research study that will utilize genetic testing to provide you more information about the possible roles of your genes in your diagnosis.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
  • Genetics and Genetic Disorders
  • Movement
Not currently enrolling

Genetic Determinants of Neurological and Developmental Disorders

The purpose of this study is to identify and genomically-characterize individuals with genetically unexplained neurodevelopmental disorders, such as epilepsy. The overarching goal is to provide patients with improved information about the underlying genetic basis of their disorder and illuminate novel genetically-defined treatment approaches in the future.

Age & Gender
  • 0 days ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Developmental
  • Genetics and Genetic Disorders
  • Rare Diseases
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