Have you recently been diagnosed with breast cancer but have not yet started treatment (other than surgery)? You may be able to take part in the UNC CogMAP study. In this study, we want to learn more about cognitive and brain function before and after cancer treatment. This will help us to better understand risk factors for experiencing cognitive difficulties during and after treatment.

Metabolism is the process your body uses to make energy. The main purpose of this study is to observe the impact of metabolic processes on cognition and behavior.

Participants are asked to come into the lab for a 1.5-hour session. During this session they will complete questionnaires and tasks. Questionnaires will ask about physical and mental health, life experiences, emotions, and cognitive associations. Tasks are designed to measure participants' sensitivity to heartbeat and stomach sensations, as well as socioemotional functioning.

Fuel for Thought: How do sugar and fat affect each other in the brain? Do you ever wonder what happens in your brain when you eat dessert? And why sugary and fatty foods are so appealing? If so, you may eligible to participate in a research study to understand the impact of sugar and fat on the brain!

Have you been diagnosed with extremity soft tissue sarcoma and are scheduled to have standard of care radiotherapy (XRT) followed by surgery to treat your cancer? XRT is effective in managing extremity soft tissue sarcoma, however, it is associated with risks, such as damage to healthy tissue, and complications in post-surgery wound healing.

Did you have head or neck cancer? Have you completed radiation in the past 3 years or more and now have dry mouth? You may be able to take part in a research study to help us learn if a gene therapy can help people with dry mouth due to radiation therapy.

Have you been diagnosed with high-risk early triple-negative breast cancer (TNBC) without mutations in the BRCA1 or BRCA2 gene? If you still have evidence of TNBC in your breast or lymph node tissue after receiving treatment and surgery, you may qualify for this clinical research study. This study will test an experimental drug combination to find out which treatment is better at delaying the return of cancer.

If you are healthy and between the ages of 18-55 years, you may be eligible to participate in a research study to find out how sugar affects the brain of individuals who carry certain genetic variants.

Are you scheduled for weight loss surgery within the next 12 months? You may be able to take part in a research study to help us learn more about your metabolic hormones, eating behaviors, stress, and weight loss before and after your surgery.

Do you have Cutaneous Lupus Erythematosus (CLE)? If you have tried antimalarials but they haven't helped your skin get better, you may be able to take part in a research study. In this study, we want to find out if a new drug improves the skin of patients with CLE. Compensation provided.