People with kidney disease that have the APOL1 risk variant are at a greater risk for developing protein in their urine and chronic kidney disease. This research study is being done to determine if the investigational drug, VX-147 can slow or stop the worsening of kidney function as well as target the underlying cause of kidney disease.

Have you or your child been diagnosed with type 1 diabetes during the past 12 months? Are you interested in helping researchers learn more about how to delay or prevent type 1 diabetes or how to treat type 1 diabetes? Join a registry to be notified of future opportunities to participate in type 1 diabetes research!

Want to help improve the treatment of people with chronic blood cancers? We are looking for healthy volunteers to take part in a simple blood-draw study. If you are generally healthy and are not taking blood thinners, you may be able to help improve treatment for patients with chronic blood cancers by donating a tablespoon of blood. This study aims to understand why individuals with chronic blood cancers have a high risk of blood clots as compared to healthy individuals, by comparing (1) the ability of blood to clot in a test tube and (2) changes in white blood cells that make them more likely to stick to blood vessels between healthy individuals and individuals with chronic blood cancers.

Are you pregnant? Are you high risk? We know it is stressful to be pregnant when you are high-risk. We are trying to learn more about how different aspects of your life - including activity, diet, environment, stress level, and social support affect pregnancy outcomes. Compensation provided.

Have you been infected with COVID-19? Are you a solid organ transplant recipient? Have you or your child received a COVID-19 vaccine or are planning to receive one? If so, you may be eligible to participate in a research study that will assess your immune response to COVID-19 infection or vaccination over a 5 year period. We are looking for children and adults aged 7-95 years, and plan to collect blood every 2-6 months over the study period. (Compensation provided for the first year).

Do you sit too much at work or home? There is strong evidence for an association between sitting and cardiovascular diseases such as coronary heart disease and stroke. In this study, we want to identify strategies to break up sitting for long periods of time. Compensation will be provided.

Do you have non-small-cell lung cancer? Did your cancer get worse after, or while you were on treatment? If so, you may be eligible to participate in a research study that uses your own modified immune cells as possible treatment.

How does your baby's environment affect their brain? A child's brain grows quickly during pregnancy and infancy. If you are pregnant in your 2nd or 3rd trimester, you may be eligible to participate in a research study to find out how your environment affects your baby's brain development. Compensation provided.

We still have a lot to learn about why people develop glomerular disease and what the best medicines are to treat these diseases. Diabetes is a common, chronic illness and many people with glomerular disease also have diabetes. Currently, there is no information telling us the best ways to treat patients with both diabetes and glomerular disease, or how to counsel them about prognosis and risks for complications. This substudy of the Cure Glomerulopathy Network brings together information and laboratory specimens from patients with diabetes and glomerular disease to speed up and improve health research for their care.

Does your child or teen have a history of wheezing or asthma? Your child may be eligible to participate in a registry that will allow us to understand how wheezing and asthma change over time in kids and teens. Compensation provided for in-person study visits. We will also be enrolling some children without a history of wheezing or asthma to serve as a comparison group.