All endpoints will evaluate the efficacy of guselkumab versus placebo, in participants with moderately to severely active UC.

EGID Partners is an online cohort of patients with eosinophilic gastrointestinal diseases (EGIDs), like eosinophilic esophagitis (EoE), eosinophilic gastritic (EG), eosinophilic gastroenteritis (EGE), and/or eosinophilic colitis (EC). It is a way to conduct important clinical research through surveys, and by filling out the initial survey, as well as follow-up surveys every 6 months, you can help answer important questions about living with EGIDs. We are also looking for people without EGIDs to provide information as well, so we can make comparisons between those do and don't have EGIDs. Adults as well as parents/caregivers of children are eligible. Find out more at www.egidpartners.org

This nationwide Internet survey in the United State examine the prevalence, associated factors and burden of bloating, distention and other gas-related symptoms and disorders in the general population, and to assess the role of diet in these problems.

The purpose of this research study is to learn more about Barrett's Esophagus and esophageal cancer by collecting data and samples (blood and tissue) for a biorepository. A biorepository is a large bank of specimens and data that are stored indefinitely and may be shared with other researchers.

The purpose of this study is to create a registry (collect data and keep it in a research database) to learn more about two methods of taking small tissue samples from your esophagus (the esophagus is the tube that carries food and liquid from your mouth to your stomach). The two methods of sampling are: 1) Using forceps that take biopsies (small tissue samples) from your esophagus, and 2) Using a brush that also takes biopsies from your esophagus. The data collected over many years will be used to determine the best way to diagnose esophageal disease.

This study is to test the effects of drug VK2809 compared to placebo on liver fat content, for patients with biopsy-proven non-alcoholic steatohepatitis with fibrosis.

The study is designed to look at Crohn's disease over a period time, from before a surgery to 12 months after the surgery has taken place. The role bacteria in the gut plays in Crohn's disease (CD) is not well understood. Which particular microbes contribute to disease remain unknown. In CD, ~70% of patients will end up requiring surgery due to chronic unrelenting complications, and ~50% require additional surgery. We hope to identify key microbes at the time of surgery in stool and tissue and correlate it over time with data collected at timepoints after surgery. We will use this data with clinical information to determine if specific microbes are associated with disease recurrence.

To evaluate the impact of the COVID-19 pandemic on life stress, emotional and physical symptoms and quality of life in the U.S. adult population, and examine the role of specific psychological factors (subconscious connectedness, neuroticism, and optimism) in modulating these effects.

The purpose of the study is validate the first measure of disease-specific quality of life in patients diagnosed with eosinophilic gastritis (EG) or eosinophilic gastroenteritis (EGE).

The purpose of this study is to find out if certain genetic factors are linked to treatment response in Barrett's Esophagus and esophageal cancer.