This project will define findings of patients referred for colonoscopy following a positive Cologuard® test using retrospective analysis of one community Gastroenterology practice.

The study is designed to look at Crohn's disease over a period time, from before a surgery to 12 months after the surgery has taken place. The role bacteria in the gut plays in Crohn's disease (CD) is not well understood. Which particular microbes contribute to disease remain unknown. In CD, ~70% of patients will end up requiring surgery due to chronic unrelenting complications, and ~50% require additional surgery. We hope to identify key microbes at the time of surgery in stool and tissue and correlate it over time with data collected at timepoints after surgery. We will use this data with clinical information to determine if specific microbes are associated with disease recurrence.

This is a 5-year, longitudinal, observational study of adult and pediatric patients (age 2 and above) undergoing IBD therapy designed to specifically address important clinical questions that remain incompletely answered from registration trials. In addition to the study database, a biospecimen repository will also be included so that translational studies of viral resistance, genomics, and biomarkers of response may be performed. Also, the right to collect retrospective data on these IBD patients will be reserved.

The purpose of the study is validate the first measure of disease-specific quality of life in patients diagnosed with eosinophilic gastritis (EG) or eosinophilic gastroenteritis (EGE).

The purpose of this research study is to learn more about Barrett's Esophagus and esophageal cancer by collecting data and samples (blood and tissue) for a biorepository. A biorepository is a large bank of specimens and data that are stored indefinitely and may be shared with other researchers.

EGID Partners is an online cohort of patients with eosinophilic gastrointestinal diseases (EGIDs), like eosinophilic esophagitis (EoE), eosinophilic gastritic (EG), eosinophilic gastroenteritis (EGE), and/or eosinophilic colitis (EC). It is a way to conduct important clinical research through surveys, and by filling out the initial survey, as well as follow-up surveys every 6 months, you can help answer important questions about living with EGIDs. We are also looking for people without EGIDs to provide information as well, so we can make comparisons between those do and don't have EGIDs. Adults as well as parents/caregivers of children are eligible. Find out more at www.egidpartners.org

• To provide investigators in the Division of Gastroenterology with the sources of clinical information for basic research and clinical studies of inflammatory bowel diseases. • To provide optimal and standardized collection of stool for such studies.