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Research Studies

UNC-Chapel Hill Division of Gastroenterology and Hepatology

39 studies match your search
Open

ALAMERE - NSI-8226-201

Are you living with eosinophilic esophagitis (EoE)? Consider joining our research study to help advance treatment options for this condition. We invite you to participate in a clinical trial comparing the effects of solrikitug, a potential new medicine, with a placebo. By joining, you'll contribute to understanding the effectiveness and safety of solrikitug in treating EoE. The study aims to evaluate its impact on tissue inflammation, difficulty swallowing, and overall quality of life. Your participation is voluntary, and you can withdraw at any time without losing medical benefits. With approximately 157 participants globally, you'll receive thorough medical monitoring throughout the 72-week study period. Plus, you'll have opportunities to discuss your experience with our team and internationally recognized EoE researcher, Dr. Evan Dellon. Make a difference in EoE research-join us today and be part of the journey towards better treatments for EoE.

Age & Gender
  • 18 years ~ 75 years
  • Male, Female, Gender Inclusive
Study Interest
  • Allergy
  • Stomach, Digestion and Gut Health
  • Women's Health
  • and 3 more
Open

Akero 107

Do you have NASH/MASH and would like to take part in a clinical trial to see if an investigational drug can help reduce the inflammation and scarring (fibrosis) in your liver? Then you may be able to participate in our upcoming Phase III Clinical trial. Inquire today!

Age & Gender
  • 18 years ~ 80 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
Open

Akero 105

Do you have NASH/MASH and would like to take part in a clinical trial to see if an investigational drug can help reduce the inflammation and scarring (fibrosis) in your liver? Then you may be able to participate in our upcoming Phase III Clinical trial. Inquire today!

Age & Gender
  • 18 years ~ 80 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
Open

GI Alpha-Gal study

Do you have Alpha-Gal Allergy AND GI symptoms such as abdominal pain, vomiting, and diarrhea? Have you experienced improvement of these symptoms on a mammalian meat-free diet? You may be eligible for our study to help UNC researchers better understand alpha-gal allergy with belly/gastrointestinal symptoms. Compensation provided.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Allergy
  • Stomach, Digestion and Gut Health
Not currently enrolling

Dupilumab for Eosinophilic Esophagitis with Severe Strictures (DESTRICT Study)

To determine the effect of an FDA-approved drug on treating patients with severe strictures and Eosinophilic Esophagitis (EoE)

Age & Gender
  • 16 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Stomach, Digestion and Gut Health
  • Ear, Nose, and Throat
Open

Obeticholic Acid for Prevention in Barrett's Esophagus

Do you have Barrett's Esophagus? Researchers are seeking volunteers to participate in a clinical trial that evaluates the effects obeticholic acid, a drug that reduces bile acids.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Stomach, Digestion and Gut Health
Not currently enrolling

PSC Symptom Interviews and Measures

We have study goals: (1) To conduct phone interviews to ask about symptoms and life impact from adult patients living with PSC; (2) To lead community advisory board discussions to decide on using existing symptom measures 'as is', modify existing measures or develop new measures to evaluate PSC symptoms; and (3) To conduct interviews with adult patients with PSC to assess their understanding and comprehension of selected symptom measures. We plan to consent and enroll up to 75 patients into a Screening database. From the database, we will select up to 24 patients to interview for Aim 1 and up to 16 patients to interview for Aim 3. Interviews will be conducted over the phone by staff at Duke University. At the end of the study, we will have 3 PSC symptom measures for use in future PSC studies.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Stomach, Digestion and Gut Health
  • Kidneys and Liver
Visit Location
100% Remote (online, phone, text)
Open

Individualized Diet Elimintation for Treatment of Eosinophilic Esophagitis (EoE)

Have you been diagnosed with Eosinophilic Esophagitis (EoE) and therapies you've tried don't work, or you aren't interested in taking drugs to treat your EoE? Are you willing to modify your diet to exclude certain foods for 8 weeks? If so, then you may be eligible to participate in a study to see if an individualized diet elimination therapy works to treat EoE.

Age & Gender
  • 16 years ~ 80 years
  • Male, Female, Gender Inclusive
Study Interest
  • Allergy
  • Stomach, Digestion and Gut Health
  • Ear, Nose, and Throat
Open

EoE Tooth Fairy Study: Environmental Risk Factors for Eosinophilic Esophagitis (EoE)

Do you have any of your baby teeth or are you a parent who has kept your child's baby teeth? Are you a young adult or a parent of a child age 25 or under? Did you know scientists can learn all about different medications, foods, and environmental exposures in a child's early life from their teeth? You may be able to take part in a research study to learn what factors increase children's risk of developing EoE (eosinophilic esophagitis)! We are looking for children and young adults (age 0-25) with or without EoE to volunteer. Compensation will be provided.

Age & Gender
  • 0 years ~ 25 years
  • Male, Female, Gender Inclusive
Study Interest
  • Child and Teen Health
  • Environment
  • Healthy Volunteer or General Population
  • and 5 more
Visit Location
100% Remote (online, phone, text)
Not currently enrolling

Dupilumab Eosinophilic Gastritis Study (DEGAS)

To see if a drug administered via injection (dupilumab) is safe and effective at reducing eosinophilic inflammation in the stomach of participants with eosinophilic gastritis (EG)/ eosinophilic gastroenteritis (EGE).

Age & Gender
  • 12 years ~ 70 years
  • Male, Female, Gender Inclusive
Study Interest
  • Stomach, Digestion and Gut Health
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