Do you have Alpha-Gal Allergy AND GI symptoms such as abdominal pain, vomiting, and diarrhea? Have you experienced improvement of these symptoms on a mammalian meat-free diet? You may be eligible for our study to help UNC researchers better understand alpha-gal allergy with belly/gastrointestinal symptoms. Compensation provided.

We have study goals: (1) To conduct phone interviews to ask about symptoms and life impact from adult patients living with PSC; (2) To lead community advisory board discussions to decide on using existing symptom measures 'as is', modify existing measures or develop new measures to evaluate PSC symptoms; and (3) To conduct interviews with adult patients with PSC to assess their understanding and comprehension of selected symptom measures. We plan to consent and enroll up to 75 patients into a Screening database. From the database, we will select up to 24 patients to interview for Aim 1 and up to 16 patients to interview for Aim 3. Interviews will be conducted over the phone by staff at Duke University. At the end of the study, we will have 3 PSC symptom measures for use in future PSC studies.

Have you been diagnosed with Eosinophilic Esophagitis (EoE) and therapies you've tried don't work, or you aren't interested in taking drugs to treat your EoE? Are you willing to modify your diet to exclude certain foods for 8 weeks? If so, then you may be eligible to participate in a study to see if an individualized diet elimination therapy works to treat EoE.

Do you have any of your baby teeth or are you a parent who has kept your child's baby teeth? Are you a young adult or a parent of a child age 25 or under? Did you know scientists can learn all about different medications, foods, and environmental exposures in a child's early life from their teeth? You may be able to take part in a research study to learn what factors increase children's risk of developing EoE (eosinophilic esophagitis)! We are looking for children and young adults (age 0-25) with or without EoE to volunteer. Compensation will be provided.

To see if a drug administered via injection (dupilumab) is safe and effective at reducing eosinophilic inflammation in the stomach of participants with eosinophilic gastritis (EG)/ eosinophilic gastroenteritis (EGE).

Have you been diagnosed with Barrett's Esophagus or Esophageal Adenocarcinoma? If so, you may be able to participate in a research study to find out if a new, minimally invasive device can collect cells from your esophagus without the need for sedation. Compensation provided.

Are you scheduled at a UNC Healthcare facility for a routine screening colonoscopy? You may eligible to participate in a voluntary research study finding out if a blood test can help detect colorectal cancer.

The purpose of this research study is to compare three different FDA approved treatments for fecal incontinence (also known as accidental bowel leakage) in men and women in terms of how well the treatments work, how safe the treatments are, and now much the treatments cost. Patients would undergo Enhanced Medical Management (EMM) for 1 month to optimize bowel function, as we have found EMM controls leakage symptoms in many individuals. Those who do not experience >75% reduction in leakage episodes would then be randomized into biofeedback, SNS, or dextranomer. Patients are followed for two years.The treatments are biofeedback therapy, sacral nerve electrical stimulation (SNS), or dextranomer injections.

we propose the creation of a prospective multi-center registry of patients with IBD and EIM, initially focusing on peripheral arthritis, the most common and understudied EIM, to better understand clinical course and management.

To learn if one kind of treatment approach, either (1) endoscopic surveillance or (2) endoscopic eradication therapy, is better, the same, or worse for treating patients with Barrett's esophagus and low-grade dysplasia.