Have you been infected with COVID-19? Are you a solid organ transplant recipient? Have you or your child received a COVID-19 vaccine or are planning to receive one? If so, you may be eligible to participate in a research study that will assess your immune response to COVID-19 infection or vaccination over a 5 year period. We are looking for children and adults aged 7-95 years, and plan to collect blood every 2-6 months over the study period. (Compensation provided for the first year).

This project seeks to adapt and test the existing Tough Talks app to address COVID vaccine hesitancy among African American young adults (AA-YA) aged 18-29.

In this study, we want to learn more about a program (STOMP) designed to improve chronic pain in people living with HIV.

The purpose of this study is to conduct interviews to hear people's thoughts and feedback on various aspects of conducting syphilis vaccine research at UNC-Chapel Hill and to ask them to complete a brief online survey after their interviews. The information that participants provide will help the clinical trial researchers to better understand what concerns people might have about syphilis vaccine research and to design clinical trials that are acceptable to potential vaccine research participants.

To comprehensively characterize the clinical, laboratory, and histopathologic features of breast cancer patients receiving care according to local standards in Malawi.

The purpose of this study is to: • Observe how LEN moves throughout the body in US cisgender women • Evaluate the safety of LEN and F/TDF for pre-exposure prophylaxis (PrEP) in US cisgender women • valuate the acceptability of LEN injections and oral F/TDF in US cisgender women Cisgender means whatever gender you are now is the same as the sex that you were assigned at birth.

To increase access to Pre-Exposure Prophylaxis (PrEP) across North Carolina. HIV Pre-Exposure Prophylaxis (PrEP) medication has been proven to be effective at preventing HIV infection when taken as prescribed. Even though PrEP has been shown to be effective, not all health care settings currently offer PrEP to their patients. Part of the reason for this is that there are not enough health care providers who prescribe PrEP, and, some people have difficulty getting the cost of PrEP and PrEP care covered. The purpose of this study is to test new ways to increase access to PrEP for people in North Carolina. The intervention will test whether providing access to resources related to PrEP care at health department sexually transmitted infection (STI) clinics will increase the number of people who start using PrEP.

To address the core problem of insufficient safe blood supply for the country, targeting the lowest risk and most receptive population for consistent donation can be successful. The 2018 population census shows that the total population aged 15 to 24 is 3,687,521 out of which 1,905,165 (52%) are males and 17% (645,000/ 3,687,521) live in urban areas clearly showing the large blood donation potential for the country (National Statistical Office, 2019). The two studies conducted in the initial Year 1 and Year 2 of the Malawi BLOODSAFE Project (2020-2022) have provided rich information on temporal and geographical patterns of blood donation and transfusion transmissible infection as well as barriers and facilitators to blood donation. Using this information, we now propose to develop a comprehensive integrated school-based and post-school donation clubs to serve as a foundation that will encourage lifelong donation and improve the supply of safe blood in Malawi.

To evaluate safety and efficacy of therapeutic vaccination with chimpanzee adenovirus (ChAdV)- and poxvirus modified vaccinia Ankara (MVA)-vectored vaccines in a sequential regimen with the Toll-like Receptor 7 (TLR7) agonist vesatolimod (VES) and two broadly neutralizing antibodies (bNAbs) in individuals with HIV-1 who started suppressive antiretroviral therapy (ART) during acute HIV-1.

The goal of this study is to develop new ways of figuring out which children with acute respiratory illnesses (like cough, cold, or flu) would benefit from antibiotic treatment. To do this, we will evaluate different combinations of vital signs, symptoms, results from tests for infections that cause respiratory illness, and measurement of the body's immune response to see which ones best predict the presence of infection that requires antibiotic treatment.