A multi-center open-label trial evaluating the efficacy and safety of daratumumab in treatment of patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposits.

This study will compare 3 different ways to educate patients with advanced chronic kidney disease about hemodialysis vascular access.

To ascertain pediatric clinician preferences for risk stratification for pediatric kidney disease.

This study is comparing two approaches for monitoring and addressing symptoms among adult patients with kidney failure who are treated with hemodialysis. For the first approach patients use an electronic system twice a month to report their symptoms. The system sends alerts to their medical team at the dialysis clinic about the reported symptoms and gives suggestions about how to manage them. The system also provides reports that show patients and their medical team the reported symptoms over time. For the second approach patients complete a quality of life questionnaire that includes questions about symptoms once a year. The questionnaire does not have follow-up support like alerts, symptom management guidance, or reports. In addition, researchers will talk to patients, dialysis clinic personnel, and medical providers about their experiences using the electronic symptom monitoring system to learn about how to best use patient-reported outcome measures in dialysis care.

Infections occurring in individuals with glomerular disease are preventable contributors to excess healthcare utilization, morbidity, and mortality, and are the leading cause of death in children with glomerular disease. Vaccination is a powerful and cost-effective method to attenuate infectious burden, and clinical guidelines recommend that patients with glomerular disease receive 23-valent pneumococcal (PPSV23) vaccine. The main objective of the study is to determine functional PPSV23 immunogenicity in a prospectively collected multicenter cohort of children with idiopathic nephrotic syndrome using measurements of anti-pneumococcal and opsonophagocytic antibody titers prior to, and 1, 3 and 12 months following PPSV23 vaccination.

The purpose of this research study is to try and teach a computer program to assess how a dialysis vascular access fistula is maturing, when it could be ready to put needles in, or when it needs to be fixed to allow it to mature better; based on the electronic stethoscope recordings.

A challenge in treating COVID-19 is early prediction of patient outcomes. Here, we develop a functional assay for patient risk stratification based on clinically observed, unique vascular signatures of COVID-19. We integrate data from this assay with patient process of care information to determine predictive metrics for risk stratification.