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UNC-Chapel Hill Division of Nephrology & Hypertension

26 studies match your search
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IgA Nephropathy Microbiome Study

The purpose of this study is to compare diet (record of the foods you eat), gut microbiome (stool sample), and cells (blood sample) in adults with IgA Nephropathy (IgAN) and compare with adults with focal segmental glomerulosclerosis (FSGS) and adults with no history of medical problems. The information we learn by doing this study may help us understand how we might be able to target the microbiome to better understand the disease process and potentially help us develop new therapies in the future.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Healthy Volunteer or General Population
  • Kidneys and Liver
  • Microbiome
Open

A Study of Atrasentan in IgA Nephropathy (ASSIST)

Atrasentan is an investigational drug. That means it has not yet been approved by the FDA as a medicine. Researchers want to find out if taking atrasentan along with a drug called an SGLT2 inhibitor is safe and helps people with IgA nephropathy.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
Open

A study to test BI 764198 in people with a type of kidney disease called focal segmental glomerulosclerosis

This study is being done to see if the study drug, called BI 764198, may help people with a type of kidney disease called focal segmental glomerulosclerosis (abbreviated FSGS). Researchers are trying to figure out if the study drug can reduce the amount of protein in your urine, also known as "proteinuria".

Age & Gender
  • 18 years ~ 75 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
Not currently enrolling

CONFIDENCE

The purpose of this study is to find out if a medicine called finerenone in combination with a medicine called empagliflozin is a safe and effective treatment for people that chronic kidney disease and type 2 diabetes.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Diabetes
  • Kidneys and Liver
  • Rare Diseases
Open

Goodpasture Disease (Anti-GBM) Research Study

Have you been hospitalized for anti-GBM disease (Goodpasture disease)? You may be able to take part in a research study to help us learn if adding a drug to your treatment could help stop inflammation faster and help protect the kidneys.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
  • Lungs and Breathing
Open

VX-147

People with kidney disease that have the APOL1 risk variant are at a greater risk for developing protein in their urine and chronic kidney disease. This research study is being done to determine if the investigational drug, VX-147 can slow or stop the worsening of kidney function as well as target the underlying cause of kidney disease.

Age & Gender
  • 18 years ~ 60 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
  • Rare Diseases
Not currently enrolling

Aurora VOCAL Study for Adolescents with Lupus Nephritis

The purpose of this study is to test a medication called voclosporin in adolescent lupus nephritis patients. Voclosporin is approved for use in adult patients with active lupus nephritis but not for children or adolescents.

Age & Gender
  • 12 years ~ 17 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
Open

INShore: is the drug obinutizumab helpful in children with nephrotic syndrome?

Does your child have frequently relapsing or steroid dependent nephrotic syndrome? This study is testing a medicine called obinutuzumab, and comparing it with another one, mycophenolate mofetil (MMF), to see which works better for children with nephrotic syndrome.

Age & Gender
  • 2 years ~ 25 years
  • Male, Female, Gender Inclusive
Study Interest
  • Child and Teen Health
  • Kidneys and Liver
  • Parents of Children
Open

Evaluating Problematic Proteinuria in Kids (EPPIK)

The purpose of the EPPIK study is to gain further experience on the use of sparsentan in children.

Age & Gender
  • 1 years ~ 17 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
  • Rare Diseases
Open

CureGN Diabetes

We still have a lot to learn about why people develop glomerular disease and what the best medicines are to treat these diseases. Diabetes is a common, chronic illness and many people with glomerular disease also have diabetes. Currently, there is no information telling us the best ways to treat patients with both diabetes and glomerular disease, or how to counsel them about prognosis and risks for complications. This substudy of the Cure Glomerulopathy Network brings together information and laboratory specimens from patients with diabetes and glomerular disease to speed up and improve health research for their care.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Kidneys and Liver
  • Rare Diseases
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