Leveraging our decades of experience studying the acute and chronic effects of traumatic brain injury (TBI) and concussion, our investigative team propose an innovative, translational approach that bridges both preclinical and clinical studies. We propose testing multiple potential preventative and therapeutic strategies in the preclinical setting, while simultaneously conducting a prospective, longitudinal study of neurologic health outcomes associated with concussion and sub-concussive exposure in former NFL players. Our prior studies of former NFL players over the past 15 years provide us with a unique opportunity to conduct a truly prospective, longitudinal study of long-term neurologic health outcomes and determine any possible association with concussion and repetitive sub-concussive exposure. In parallel, we have developed animal models of repeated concussions (repetitive mild TBI [rmTBI]) and chronic traumatic encephalopathy (CTE). We have studied the effects of readily translatable preventative and therapeutic strategies, including the N-methyl-D-aspartate (NMDA) receptor antagonist memantine, low dose carbon monoxide

The purpose of this study is to learn more about factors that contribute to exercise-induced fatigue in women.

The purpose of this study is to assess the physical activity practices of college-age Native American adults.

Do you have a history of ACL reconstruction? You may be eligible to participate in a study using virtual reality and mindfulness meditation! We aim to explore psychological factors that may impact return to play outcomes after ACL reconstruction.

The purpose of this project is to quantitatively and qualitatively examine the adherence and acceptability of the Oura Ring, and to examine the accuracy of the Oura Ring to measure physical activity. *This study is a collaboration with the UNC Sports Medicine Institute*

The purpose of this research study is to learn about people's reasons for drinking alcohol. We will do this by testing a new survey and asking people to tell us their opinions about the individual survey questions and the survey overall. The information we learn from this study will help us to improve survey questions so we can do a better job of asking people about their reasons for drinking alcohol in future studies.

This is a research study to find out which type of sedentary behavior, or sitting, is most strongly associated with cardiovascular disease (CVD) risk in endometrial cancer survivors. Additionally, we hope to better understand your perception of sedentary behavior and sedentary behavior reduction. The findings from this research study will be used to design a future sedentary behavior reduction intervention for endometrial cancer survivors. Participation in this study includes one assessment visit (during your regularly scheduled clinic visits) where we will measure your blood pressure and arterial stiffness using a blood-pressure like non-invasive device. Additionally, during this visit, you will answer questionnaires, complete a short physical function test (i.e., balance, walking, standing), and be instructed in how to use an accelerometer (movement tracking device worn on your upper thigh) paired with a smart-phone application that will ask you questions about your physical activities and sedentary behavior for 7-days following your

Interested in participating in future research studies? Whether you have had a previous ACL injury or not, you may be able to take part in several research study opportunities. This registry simply collects your contact information and then we will reach out if any study opportunities are available.

The purpose of the study is to understand gait patterns of healthy, uninjured individuals. *This study is a collaboration with the UNC Sports Medicine Institute*

The purpose of this study is to understand reporting behaviors of concussion symptoms among young adult athletes who have participated in organized sport when concussion occurs both inside and outside of sport. Focusing on reporting behaviors of non-SRCs will contribute to a more holistic view of concussion reporting behaviors which may enhance concussion reporting interventions to improve reporting patterns and athlete safety in the future.