To assess hepatitis C virus treatment and hepatocellular carcinoma surveillance within practices and gauge the feasibility of a program to implement point-of-care risk stratification tools and screening referral systems.

To build a state-wide blended instructional model to strengthen K-12 remote instruction, content, and access across North Carolina's rural and distressed communities.

The purpose of this research project is to better understand the experiences of those who have participated in Project PROMISE and the Rural Health Initiative, and how these experiences have impacted the career and education trajectory of these students.

The purpose of this research study is to collect data about attitudes towards social topics in the news.

Domestic violence intervention programs (DVIPs), also known as batterer intervention programs (BIPs), are court-mandated and self-referred programs designed to address domestic violence perpetration through psycho-educational approaches and/or cognitive behavioral therapy. By building on the extant evidence base and conducting formative research, we will identify DVIPs that have demonstrated effectiveness and innovative practices, including the utilization of restorative justice frameworks, and assess their curricula, service delivery approaches, partnerships, and administrative structures. We will use this information as the basis to determine DVIP best practices, with the goal of improved outcomes in mitigating domestic violence.

This study aims to design and improve tools that can be used to select strategies for improving colorectal cancer screening in different settings and populations. Interviews, surveys, and focus groups will be conducted with individuals who make decisions related to colorectal cancer screening interventions about their understanding, preferences, and suggestions related to these tools and intervention strategies.

We propose to develop and test health messages about e-cigarettes and study their impact. Findings will inform e-cigarette warning policies and communication campaigns.

This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumomab is an antibody, which is a protein that identifies and targets specific molecules in the body. Blinatumomab searches for and attaches itself to the cancer cell. Once attached, an immune response occurs which may kill the cancer cell. Nivolumab is a medicine that may boost a patient's immune system. Giving nivolumab in combination with blinatumomab may cause the cancer to stop growing for a period of time, and for some patients, it may lessen the symptoms, such as pain, that are caused by the cancer.

The purpose of this research study is to evaluate the effects of Sickle Cell Disease on the state of coagulation and effects on generation of certain coagulation proteins. People with sickle cell disease tend to have a higher rate of thrombosis which is not fully understood. Through this study, we hope to gain a better understanding of the effects of sickle cell disease on turning on coagulation that ultimately leads to a thrombotic event.

We will collect stem cells from individuals with autism to investigate brain development in sibling pairs who do not share a diagnosis of ASD, as well as examine associations between brain growth and variation in ASD-related behaviors.