This phase 3 trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type 1. Selumetinib works by blocking some of the enzymes needed for cell growth and may kill tumor cells. Carboplatin and vincristine are chemotherapy drugs that work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. The overall goal of this study is to see if selumetinib works just as well as the standard treatment of CV for patients with LGG. Another goal of this study is to compare the effects of selumetinib versus CV in subjects with LGG to find out which is better. Additionally, this trial will

This study will evaluate the use of MMUD PBSC in adults and explore the safety and efficacy of MMUD BM in pediatric recipients with hematological malignancies who may lack other donor options.

Better understand symptoms that occur after liver-directed treatments for liver cancer

The purpose of this study is to develop a prospective longitudinal cohort/registry of lymphoma patients in Malawi to address a lack of prospective longitudinal data related to lymphoma in sub-Saharan Africa, and to serve as a foundation for developing optimal treatment strategies in this challenging environment.

This study is being conduced to assess the feasibility of conducting multi-center prospective studies on surgical excision of suspected OSSN lesions in SSA in people living with HIV/AIDS (PLWHA).

The CMR is a population based breast imaging registry for women screened for breast cancer in NC.

The purpose of this research study is to assess the patient-level, healthcare provider/system-level, and community-level barriers to resolving abnormal mammograms and initiation of treatment of breast cancer in the 3 geographic regions of North Carolina: the greater Charlotte area, the Northwest, and the Northeast. These areas include the following counties: Anson, Cabarrus, Cleveland, Gaston, Lincoln, Mecklenburg, Stanly, Union, Edgecombe, Halifax, Nash, Northampton, Wilson , Ashe, Alleghany, Surry, Stokes, Watauga, Wilkes, Yadkin, Forsyth, Avery, Caldwell, Alexander, Iredell, Davie, Davidson, Burke, Catawba, and Rowan. These barriers can include obtainment of biopsies and other diagnostic procedures for resolving abnormal mammograms abnormalities or breast symptoms, access to care providers after breast cancer diagnosis, and initiation of appropriate surgical, chemotherapy, and radiation treatments after diagnosis.

We will identify changes in the numbers, seriousness, and outcomes of breast cancers diagnosed during the COVID-19 pandemic, compared to before the pandemic.

For more information, please visit our website: https://cecs.unc.edu The purpose of this research study is to learn more about the diagnosis, treatment, and survivorship experiences of adults with endometrial cancer. Initial enrollment goals are for 1,800 adults living in North Carolina at the time of their recent first diagnosis of endometrial cancer. This project will provide important data for integrating tumor biology, access to care, and other factors to identify contributors, and potential areas for intervention to address endometrial cancer disparities. Study staff will pursue annual follow-ups with participants, requesting updates to treatment status and quality of life measures for approximately 5yrs.

The purpose of this study is to create a biobank by collecting and storing specimens, such as blood and tissue, along with medical information such as demographics and treatment, from a large group of patients with pancreatic tumors. This biobank can then be used by future studies focused on pancreatic tumors.