This partially randomized phase II/III trial studies how well cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or liver cancer after surgery. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving combination chemotherapy after surgery may kill more tumor cells.
This phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving iobenguane I-131 or crizotinib and standard therapy may work better compared to crizotinib and standard therapy alone in treating younger patients with neuroblastoma or ganglioneuroblastoma.
The purpose of this research study is to learn more about Barrett's Esophagus and esophageal cancer by collecting data and samples (blood and tissue) for a biorepository. A biorepository is a large bank of specimens and data that are stored indefinitely and may be shared with other researchers.
To comprehensively characterize the clinical, laboratory, and histopathologic features of breast cancer patients receiving care according to local standards in Malawi.
We aim to characterize work exposures and illness in Badin, North Carolina--the site of an aluminum smelting facility for nearly 100 years.
To conduct focus groups and semi-structured interviews of parents with cancer - and their co-parents - about their experiences communicating with their minor children about cancer to inform the development of a communication intervention support tool.
To evaluate the feasibility and acceptability of a novel psychosocial intervention for parents with advanced cancer and their co-parents.
The purpose of this study is to find better ways to diagnose, treat and prevent cancers in children, adolescents and young adults. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.
To identify treatment goals and factors that affect treatment selection for older patients with advanced melanoma through semi-structured interviews with patients and treating physicians.
This is a research study to compare quality of life (QOL) and physical function impairment among breast cancer and lymphoma survivors in Malawi to age- and sex-matched controls, using the PROMIS survey and objective performance-based measures.