Can we increase the clinical complete response rate (tumor disappears by exam, endoscopy, and imaging) by adding a 3rd drug (irinotecan) to the standard regimen of FOLFOX or CAPOX given following long-course chemoradiation for patients with locally advanced rectal cancer? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your rectal cancer. The usual approach is defined as care most people get for locally advanced rectal cancer.

Do you have newly-diagnosed multiple myeloma? If so, you may be able to participate in a research study looking at the safety, efficacy, and tolerability of giving isatuximab in combination with lenalidomide and dexamethasone at lower doses.

Have you been diagnosed with multiple myeloma that has not responded to treatment or has come back after treatment? If so, you may be able to take part in a research study looking at the safety and efficacy of giving a new drug called ABBV-383 to patients with relapsed/refractory multiple myeloma.

The purpose of this observational study is to follow Endometrial Cancer patients through standard of care treatment of their Endometrial Cancer and collect biomedical and patient reported outcomes data.

Este estudio analizará el efecto que tiene la ideología de género y la ideología lingüística en algunas formas novedosas del español. In this study, we want to learn how gender and beliefs and attitudes about language affect how people feel about aspects of the Spanish language.

The purpose of this study is to compare the effectiveness of the drug megestrol alone, or combined with metformin, on the growth of Endometrial Intraepithelial Neoplasia.

The purpose of this study is to test if a hormonal drug Letrozole used either by itself or by adding it to the usual combination of chemotherapy drugs can help lower the chance of your ovarian or peritoneal cancer from growing or spreading.

We're all different. But when we visit the doctor, our treatments are often the same. We think one day health care should be tailored for you. This is called precision medicine. And research can help us get there. Taking part in the All of Us Research Program involves sharing information about your health, habits, and what it's like where you live. If you are 18 or older and live in the United States, you may be able to take part!

The goal of the study is to understand why teams perform better than individuals. In the study, participants will work in small groups of 2-4 members to solve a simple logic puzzle. It is a fun and engaging study to explore why teams perform better than individuals. If you are a student at UNC and 18 years or older, you may be able to take part.

Have you been diagnosed with uterine cancer called endometrial serous carcinoma or carcinosarcoma? If so, you may be able to take part in a research study to test if adding a drug or drugs that target HER2 proteins in addition to the usual combination of chemotherapy drugs could prevent your cancer from returning or shrink your cancer.