This is a Phase III study to help us improve outcomes of patients with ER+/HER2- early breast cancer with intermediate or high risk for disease recurrence. This study is for patients who have completed definitive locoregional therapy and standard adjuvant endocrine therapy for at least 2 years and up to 5 years without disease recurrence. In this study, we want to learn if a new oral "SERD" therapy called Camizestrant is helpful in reducing chance of recurrence. Talk to your Medical Oncologist for more information about this trial.

We are doing a research study of people who both smoke and vape. The purpose of this study is to learn more about your opinions on health messages.

This is a research study to investigate how collecting information about treatment-related side effects directly from patients can help manage the side effects associated with certain oral chemotherapies in patients with metastatic renal cell carcinoma.

The purpose of this study is to learn more about the safety and effectiveness of the study drug (INCB057643) as monotherapy for participants with relapsed or refractory myelofibrosis.

In this study, we want to learn if existing services meet the needs of people who experience crime in North Carolina. Specifically, we will focus on whether these services meet the needs of crime victims from historically underserved populations. We also want to learn whether service accessibility is different across the state. Although the assessment is meant to cover all North Carolinians, the GCC and research team have identified specific priority populations, including: veterans, immigrants, refugees, people with disabilities, older adults, LGBTQ+ individuals, teens, people from religious minority groups, people who are unhoused/experiencing homelessness, co-victims of homicide, indigenous communities, people with limited English proficiency, and people of color.

Are you a woman aged 65 years or older with early stage breast cancer? Have you or are you scheduled to receive a lumpectomy? If so you may be able to take part in a clinical trial to measure quality of life after breast cancer treatment.

The purpose of this research study is to learn whether there are pre-treatment factors that impact quality of life and function 3 years or more after primary treatment of breast cancer. The factors we will look at in this study may include patient characteristics, specific breast cancer diagnosis, treatments, toxicities or adverse events during treatment.

The purpose of this study is to see whether an infusion of stem cells improves lupus disease activity when compared with a placebo infusion. Other studies have shown that stem cells help reduce inflammation and are thought to be safe. This study will help confirm whether this is an effective and safe treatment for lupus.

In this study, we want to find out more about how adults learn a second language, specifically how native speakers of America English learn Russian.

This purpose of this study is to learn the best way to build advocacy skills for parents/caregivers of transition age youth with IDD. The goal is to improve parent and youth health and emotional well-being. Parents will attend a group with other parents; the groups will meet 4 times, once a week for 1 hour. The research team will collect 4 surveys from parents, 4 brief surveys from youth if the parent feels they are able to provide information, 4 audio-recordings of parent-provider conversations, and video-recordings of group sessions. Parents and youth will be compensated for their time.