We are performing a clinical study to determine the optimal frequency for medications for infected pleural fluid, referred to as intrapleural enzyme therapy (IET). Participants will either receive once daily IET or twice daily IET. We hypothesize that once daily IET will be non-inferior to twice daily IET.

The purpose of this study is to understand what helps students at UNC thrive-academically, socially, and personally. Earlier this year, we conducted a survey to measure student well-being, but numbers alone don't tell the full story. Now, we are interviewing students to learn more about their experiences. These interviews will help us understand what supports student success and what challenges students face. Our goal is to provide UNC with better information to improve campus life, mental health resources, and academic support. By listening to students, we hope to make UNC a place where more students can flourish.

This research uses the Attitudes Related to Trauma-Informed Care (ARTIC) Scale to gauge the readiness of school mental health practitioners (i.e., school psychologists, social workers, and counselors) to shift toward trauma-sensitive systems. Despite the reliance on school mental health practitioners in this movement, little research exists on their preparedness for and training in trauma-informed approaches. In hope of better situating schools to act as buffers against the adverse effects of childhood trauma, this research seeks to inform graduate and professional-level training on disciplinary practice, causes of student behavior, and the protective nature of secure adult relationships.

We will collect stem cells from individuals with autism to investigate brain development in sibling pairs who do not share a diagnosis of ASD, as well as examine associations between brain growth and variation in ASD-related behaviors.

We are looking for links between cystic fibrosis outcomes and a history of intimate partner violence.

The purpose of this research study is to evaluate the effects of Sickle Cell Disease on the state of coagulation and effects on generation of certain coagulation proteins. People with sickle cell disease tend to have a higher rate of thrombosis which is not fully understood. Through this study, we hope to gain a better understanding of the effects of sickle cell disease on turning on coagulation that ultimately leads to a thrombotic event.

This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumomab is an antibody, which is a protein that identifies and targets specific molecules in the body. Blinatumomab searches for and attaches itself to the cancer cell. Once attached, an immune response occurs which may kill the cancer cell. Nivolumab is a medicine that may boost a patient's immune system. Giving nivolumab in combination with blinatumomab may cause the cancer to stop growing for a period of time, and for some patients, it may lessen the symptoms, such as pain, that are caused by the cancer.

The primary endpoint for this study is subjects achieving either a decrease in Urgency Numeric Rating Scale (NRS) score of ≥ 2 points, or a decrease in score of ≥ 30%, at 12 weeks. Success is defined as ≥ 50% of enrolled subjects meeting the primary endpoint.

We propose to develop and test health messages about e-cigarettes and study their impact. Findings will inform e-cigarette warning policies and communication campaigns.

To evaluate the impact on learning patient-centered care in the context of trauma assessments using a virtual reality educational compared to a traditional powerpoint tool.