The purpose of this study is to determine if treating germinomas with chemotherapy followed by a lower dose of radiotherapy (RT) can be as effective as the current standard of care. Specifically, our primary aim is to determine whether 12 Gy whole ventricular irradiation (WVI) and 12 Gy tumor boost would maintain similar efficacy compared to ACNS1123 stratum 2 as measured by event-free survival (EFS) in eligible patients with localized primary central nervous system (CNS) germinoma who present with serum and/or CSF human chorionic gonadotropin-beta (hCGß) = 100 IU/L and normal AFP, and meet complete response (CR) or continued complete response (CCR) criteria following chemotherapy/second-look surgery (Stratum 1). We are attempting to build upon the excellent results of ACNS1123 stratum 2 by reducing the RT dose even further for patients in a CR after chemotherapy.

We want to find out how people in North Carolina think about climate change and clean energy. To do this, we ask participants to sort statements about topics like protecting communities, using renewable energy, and paying for projects. By looking at how people group these statements, we can see what ideas are important to them. This information will help leaders and communities work together on plans that keep everyone safer and healthier in the face of climate challenges.

This study looks at the thoughts, beliefs, and reasons behind how gun owners in North Carolina store their guns when they have children, or have children who come to the location where their gun is stored. The results will help create gun safety programs that fit the needs of different communities.

To learn about more effective ways the health care system in Zambia can care for people with non-communicable diseases (NCDs) who are also living with HIV.

The purpose of this protocol addendum is to provide participants from Study LOXO-NGR-21001 (J3T-OX-JZTA), who continue to receive benefit from LOXO-260, the opportunity for continued access to LOXO-260.

The purpose of this single-arm phase 2 study is to evaluate the efficacy of digoxin in treating relapsed non-SHH, non-WNT medulloblastoma in pediatric and young adult patients.

This study explores the response of the adjacent gum tissue to a type of dental filling material.

To test an intervention for healthcare providers that combines provider education and patient resources to increase referrals to an arthritis management program

In this research study, we want to learn more about using DNA sequencing for individuals with severe mental illness. This may give clues about health risks now and in the future. You are being asked to participate in this research study because DNA sequencing may improve our understanding of schizophrenia, and what may be causing the type of illness that you have.

The purpose of this research study is to collect and store blood samples from patients with heart disease at UNC-Chapel Hill for use in future research. Investigators will use these blood samples to identify new ways to measure substances made by our bodies that may help predict risk for developing heart disease or response to certain medications.