Assessing the safety and effectiveness of a higher dose of semaglutide for weight loss

The purpose of this research study is to examine the impact of fat exposure on sugar metabolism in the human brain.

In this study, we want to learn more about immune responses to anti-cancer drugs in people diagnosed with muscle invasive bladder cancer. This is a study for patients who have not received cisplatin and are scheduled to undergo surgery with either radical cystectomy or repeat bladder tumor resection followed by chemotherapy and radiation.

The goal of this study is to learn more about what happens when cancer drugs that target specific changes in a tumor's DNA are used to treat tumors that have those DNA changes. We call the use of these types of drugs targeted therapy. A targeted therapy delivers a treatment that is aimed at a specific molecular feature of the cancer cell. The cancer cell being targeted contains a change in the DNA that results in the production of abnormal proteins. These proteins let the cancer cells grow uncontrollably or prevent the body from eliminating the cancer cells. The targeted therapy prevents the abnormal proteins from stimulating the growth of the cancer.

A phase III randomized multi-center study designed to compare the efficacy of Crenolanib with that of Midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treatment (arm B). Potentially eligible subjects will be registered and tested for the presence of FLT3 mutation. Once the FLT3 mutation status is confirmed and additional eligibility is established, subject will be randomized and enter into the treatment phase.

Do you have Merkel cell carcinoma (MCC) that has spread to the lymph nodes? Have you had surgery or radiation therapy? If so, you may be able to take part in a research study to find out how the study drug, avelumab, works for people with MCC. We want to learn if this study drug will help prevent the cancer from coming back.

Do you want to help in the design of a new device that can electronically measure and track your strength? We are testing a new system that uses an electronic resistance exercise band and an 'app' designed for older adults to improve strength and prevent weakness. If you have an interest, you may be able to share your opinions on the device with us! We will provide $50 in gas card incentives.

The risk factors that drive health are unique to various patient populations and different patient populations use different language to communicate their health risk factors. The health risk factors and language that patients use also differs by locations. We are holding focus group sessions with family medicine physicians, senior patients, caregivers of senior patients, patients experiencing homelessness, and patients experiencing food insecurity to gain a deeper understanding of the major health risk factors they face and the words they use to describe them.

The purpose of this study is to look at a new cell therapy, MT-401, and determine the best dose for treating AML. The study will also look at the safety, tolerability, and effectiveness of this new therapy.

Do you have type 2 diabetes and find it difficult to lose weight with diet and exercise alone? If your BMI falls in the obesity range, you may be able to participate in a research study to find out if a higher dose of semaglutide is more effective for weight loss and blood sugar control.