Researchers are collecting data on lung imaging to evaluate how well a person's lungs are working which will provide additional information about lung disease and how such diseases respond to treatment. The purpose of this study is to evaluate the use of inert (non-reactive) gas mixed with oxygen as contrast agent to image the airway spaces in normal human lungs and the lungs of persons with cystic fibrosis. A contrast agent helps the investigator to see spaces inside your lungs that are normally not visible. These images will be compared with spirometry (a non-imaging measure of global lung function used routinely in the clinic).

Are you living with HIV? Do seek your care at the UNC Infectious Diseases Clinic? If so, you are eligible to participate in Database study! Participating is at no expense to you, and there are no study visits. You would be contributing to increasing knowledge about HIV and furthering the HIV research field.

We are looking for people who are between the ages of 30-70 to join a national health study to help us better understand the impact of chronic health conditions on people living with HIV. Both people living with HIV and people without HIV are invited to take part.

The purose of this study is to determine if in utero biologic and immunomodulator exposure leads to higher rates of malignancy, infection, immune mediated disease, neurologic disorders and other health issues out to 18 years from exposure

The purpose of this study is to follow patients who were diagnosed with HIV-1 infection during this acute infection stage to look at clinical and laboratory markers of HIV infection, over time. Individuals joining this study may or may not be on treatment for their HIV. No treatment is provided in this study. Participants may be asked to provide blood samples on this study.

The purpose is to better understand the function of newly identified genes that when mutated cause the disease primary ciliary dyskinesia (PCD), or clinical disorders that share clinical features of PCD. PCD is a rare disease that is caused by defects in the structure or function of cilia that move mucus and inhaled foreign material, including bacteria and viruses, out of the airways. By understanding how the proteins encoded by these genes function and how this function is altered in disease, we may be able to improve the treatments available for PCD and other airway diseases.

Collect various specimens (spit, sputum, sweat, blood, etc) to bank for research purposes.

The purpose of this research study is to evaluate the effects of Sickle Cell Disease on the state of coagulation and effects on generation of certain coagulation proteins. People with sickle cell disease tend to have a higher rate of thrombosis which is not fully understood. Through this study, we hope to gain a better understanding of the effects of sickle cell disease on turning on coagulation that ultimately leads to a thrombotic event.

We are aiming to create and test a questionnaire that measures symptoms related to a condition called eosinophilic esophagitis

The purpose of this research study is to learn about the structure and function of the upper GI tract epithelium (the lining of the food tube, or esophagus, stomach, and small bowel, or duodenum) in normal people and those with disease, especially those with eosinophilic esophagitis (EoE) or gastroesophageal reflux disease ("acid reflux" or GERD).