The goal of this study is to develop new ways of figuring out which children with acute respiratory illnesses (like cough, cold, or flu) would benefit from antibiotic treatment. To do this, we will evaluate different combinations of vital signs, symptoms, results from tests for infections that cause respiratory illness, and measurement of the body's immune response to see which ones best predict the presence of infection that requires antibiotic treatment.

The purpose of this study is to tell if a disinfectant wipe with a blue dye additive increases the thoroughness of cleaning and disinfection and reduces contamination.

The purpose of this study is to: • Observe how LEN moves throughout the body in US cisgender women • Evaluate the safety of LEN and F/TDF for pre-exposure prophylaxis (PrEP) in US cisgender women • valuate the acceptability of LEN injections and oral F/TDF in US cisgender women Cisgender means whatever gender you are now is the same as the sex that you were assigned at birth.

To evaluate safety and efficacy of therapeutic vaccination with chimpanzee adenovirus (ChAdV)- and poxvirus modified vaccinia Ankara (MVA)-vectored vaccines in a sequential regimen with the Toll-like Receptor 7 (TLR7) agonist vesatolimod (VES) and two broadly neutralizing antibodies (bNAbs) in individuals with HIV-1 who started suppressive antiretroviral therapy (ART) during acute HIV-1.

To address the core problem of insufficient safe blood supply for the country, targeting the lowest risk and most receptive population for consistent donation can be successful. The 2018 population census shows that the total population aged 15 to 24 is 3,687,521 out of which 1,905,165 (52%) are males and 17% (645,000/ 3,687,521) live in urban areas clearly showing the large blood donation potential for the country (National Statistical Office, 2019). The two studies conducted in the initial Year 1 and Year 2 of the Malawi BLOODSAFE Project (2020-2022) have provided rich information on temporal and geographical patterns of blood donation and transfusion transmissible infection as well as barriers and facilitators to blood donation. Using this information, we now propose to develop a comprehensive integrated school-based and post-school donation clubs to serve as a foundation that will encourage lifelong donation and improve the supply of safe blood in Malawi.

To increase access to Pre-Exposure Prophylaxis (PrEP) across North Carolina. HIV Pre-Exposure Prophylaxis (PrEP) medication has been proven to be effective at preventing HIV infection when taken as prescribed. Even though PrEP has been shown to be effective, not all health care settings currently offer PrEP to their patients. Part of the reason for this is that there are not enough health care providers who prescribe PrEP, and, some people have difficulty getting the cost of PrEP and PrEP care covered. The purpose of this study is to test new ways to increase access to PrEP for people in North Carolina. The intervention will test whether providing access to resources related to PrEP care at health department sexually transmitted infection (STI) clinics will increase the number of people who start using PrEP.

The purpose of this project is to understand, from the perspective of formerly incarcerated individuals, the barriers and facilitators that people released from prison experience in establishing and engaging with health care, and how those barriers and facilitators may be impacted by participation in the FIT and FIT Connect transitional health care programs.

To assess the influence of HIV-related and CVD-related variables in the existing WIHS study, including viral load, immune dysfunction, inflammation, metabolic disorders, HIV medications, gut microbiota, and metabolomics, on CVD risk as measured by cIMT.

The primary objective of the proposed project is to demonstrate the effects of limited physical facility infrastructure, diminished supplies, and gaps in Infection Prevention and Control (IPC) knowledge among Healthcare Personnel on IPC practice implementation at the health facility level to inform efficient and effective future improvement efforts.

The SELIGO study assesses perceptions of HIV treatment - including long acting injectable antiretroviral therapy (LAI ART) - among people living with HIV infection (PLWH) and HIV healthcare providers (HCPs) to develop strategies and tools to facilitate shared decision-making by patients and provider considering HIV therapy options.