The primary objective of the proposed project is to demonstrate the effects of limited physical facility infrastructure, diminished supplies, and gaps in Infection Prevention and Control (IPC) knowledge among Healthcare Personnel on IPC practice implementation at the health facility level to inform efficient and effective future improvement efforts.
To assess the influence of HIV-related and CVD-related variables in the existing WIHS study, including viral load, immune dysfunction, inflammation, metabolic disorders, HIV medications, gut microbiota, and metabolomics, on CVD risk as measured by cIMT.
The purpose of this expanded access IND (compassionate use) program is to provide tecovirimat for treatment or prevention of non-variola orthopoxvirus infections (e.g., vaccinia, monkeypox, cowpox or other human virus infection identified as an orthopoxvirus) and secondary treatment of complications from replication-competent vaccinia vaccine in adults and children.
To demonstrate efficacy of Bexsero in prevention of urogenital and/or anorectal gonococcal infection. To estimate efficacy of Bexsero in prevention of overall gonococcal infection and by anatomical site (urogenital, anorectal or pharyngeal). To assess safety of Bexsero.
To evaluate the efficacy of bemnifosbuvir (BEM) compared with placebo in reducing all-cause hospitalization or all-cause death in COVID-19 outpatients receiving only supportive care.
The purpose of this study is to see how safe and tolerable SLGN is, and how well it reduces the amount of hepatitis B virus in people with CHB and HIV. Results from this study could help evaluate whether SLGN can lower the amount of hepatitis B virus in blood and prevent illness in people with CHB and HIV, without the need for life-long therapy. SLGN has not been tested in people with HIV
To increase access to Pre-Exposure Prophylaxis (PrEP) across North Carolina. HIV Pre-Exposure Prophylaxis (PrEP) medication has been proven to be effective at preventing HIV infection when taken as prescribed. Even though PrEP has been shown to be effective, not all health care settings currently offer PrEP to their patients. Part of the reason for this is that there are not enough health care providers who prescribe PrEP, and, some people have difficulty getting the cost of PrEP and PrEP care covered. The purpose of this study is to test new ways to increase access to PrEP for people in North Carolina. The intervention will test whether providing access to resources related to PrEP care at health department sexually transmitted infection (STI) clinics will increase the number of people who start using PrEP.
The purpose of this study is to: • Observe how LEN moves throughout the body in US cisgender women • Evaluate the safety of LEN and F/TDF for pre-exposure prophylaxis (PrEP) in US cisgender women • valuate the acceptability of LEN injections and oral F/TDF in US cisgender women Cisgender means whatever gender you are now is the same as the sex that you were assigned at birth.
The primary objective of this study is to document epidemiological and ecological trends in both outpatient and inpatient cases of ARI in Kasese District in southwestern Uganda. We will also establish of a network of healthcare facilities to conduct research on preventing and improving the management of ARI in this region.
To address the core problem of insufficient safe blood supply for the country, targeting the lowest risk and most receptive population for consistent donation can be successful. The 2018 population census shows that the total population aged 15 to 24 is 3,687,521 out of which 1,905,165 (52%) are males and 17% (645,000/ 3,687,521) live in urban areas clearly showing the large blood donation potential for the country (National Statistical Office, 2019). The two studies conducted in the initial Year 1 and Year 2 of the Malawi BLOODSAFE Project (2020-2022) have provided rich information on temporal and geographical patterns of blood donation and transfusion transmissible infection as well as barriers and facilitators to blood donation. Using this information, we now propose to develop a comprehensive integrated school-based and post-school donation clubs to serve as a foundation that will encourage lifelong donation and improve the supply of safe blood in Malawi.