Do you have advanced melanoma that has progressed on treatment? Do you have a tumor longer than 1cm in length? If so, you might be able to take part in a study that compares a study treatment (Vusolimogene Oderparepvec and Nivolumab) with your physician's choice of standard of care treatment. Compensation provided.

Have you been diagnosed with hormone receptor (HR+) and human epidermal growth factor receptor 2 (HER2)-negative recurrent or metastatic breast cancer? If so, you may be eligible for a clinical trial investigating the combination of endocrine therapy with alisertib.

Have you been diagnosed with cancer. If so, you may be able to take part in a research study looking to improve cancer care for patients whose treatment outcomes have led to challenges in their quality of life.

The purpose of this research study is to evaluate the effects of 7% hypertonic saline (HS) delivered by nebulizer on mucociliary clearance (MCC) - a test that shows the rate at which a person's lungs can clear inhaled particles. We will compare the rate of MCC at baseline (before treatment with HS), with MCC after a single dose of HS (acute treatment), and with MCC after two weeks of treatment with HS twice a day after 12 hours from the last dose of HS (sustained effect). We will also assess response to HS with other outcomes (lung function testing, changes in phlegm/mucus, and survey responses). If we find there is a sustained effect of HS, this would support the use of HS as part of airway clearance for people with bronchiectasis.

The purpose of this research study is to gain insight into how people interact with some of Spotify's features including Discover Weeklyl, DJ, and Daylist. We want to learn more about the factors that influence how users discover new music when using these features.

The purpose of this research study is to investigate how human interpret some predictive learned by AI systems when detecting deceptive hotel reviews and how AI explanations can shape human understanding. For instance, the AI system learns that words like "floor" and "bathroom" are highly predictive of genuine reviews and words like "husband" and "luxury" are highly predictive of deceptive reviews. While the AI system highlights these words by learning from the data, the association between these words and the outcome are not easy to comprehend for humans. Thus, our goal of this research is to investigate how participants interact with machine-generated explanations that are unintuitive, and how participants make use of our developed visualizations and tools to make sense of these unintuitive features.

Is your child being hospitalized at UNC Youth Behavioral Health for suicidal thoughts or behaviors? If so, you may be eligible to participate in a research study to identify the risk factors associated with recurrence of suicidal thoughts after psychiatric hospitalization. Both you and your child must participate to be eligible for the research study. Compensation provided.

Are you a patient with advanced basal-like pancreatic adenocarcinoma? If so this could the a Trial for you to as this is a Phase I/II trial is to evaluate the safety, efficacy and tolerability of low-dose EGFR inhibitors in combination with bi-weekly gemcitabine/nab-paclitaxel (GnP) in subjects with basal tumors

Do you have Recurrent endometrial cancer,Recurrent, high-grade serous epithelial ovarian, primary peritoneal, or fallopian tube cancer that has progressed during or after standard treatments? If so, you may be able to take part in a research study looking at the safety of giving a treatment of test drug IMGN151-1001 to patients with these types of cancer

In this study, we want to see how giving birth affects stress chemicals in the body. We will focus on a stress hormone called cortisol and check its levels in people who gave birth, from 3 to 12 months after giving birth.