This study has 2 purposes: to assess the immediate safety, tolerability, and effectiveness of leniolisib in pediatric patients (aged 1 to 6 years) with activated phosphoinositide 3-kinase delta (PI3Kd) syndrome (APDS). The 2nd purpose is to assess the long term safty and tolerability of leniolisib in the same population.

It is well-documented in the literature that those who have performed well on standardized tests are likely to continue to perform well. This study will interview volunteers from UNC-CH School of Medicine that are high-performing test-takers, and otherwise, in an attempt to identify qualities, characteristics, or themes shared among those who consistently perform well on tests.

This study will look at the relationship between cardiovascular disease risk factors and social stress in Hispanic/Latinos with the presence of an enlarged heart or the pumping function of the heart, using echocardiography and vascular tonometry.

To determine what harm reduction services are being offered by rural pharmacies in 7 states.

The primary objective for this registry is to prospectively study the natural history of IBD, the prevalence and incidence of comorbidities, and targeted adverse events, as well as the utilization patterns and the comparative effectiveness and comparative safety of approved IBD treatments.

In this study, listeners are asked to wear headphones or listen to sounds through a computer and make decisions about what they hear or see. We are interested in how listeners with normal hearing and hearing loss understand speech and access language.

The purpose of this study is to understand user's perspectives on VR.

Randomized trial testing treatment of ulcerative pyoderma gangrenosum

Analyze biospecimens and conduct analyses on the association between endocrine disrupting chemicals and child neurodevelopment and growth.

This study is comparing two ways of treating Atrial Fibrillation (AF). Patients will either take continuous anticoagulation medications, or they will wear AF-sensing smartwatches and take anticoagulation medications for 30 days after an AF event.