The purpose of this study is to learn more about how an investigational drug (tarlatamab) works in people with extensive-stage small cell lung cancer. In this study, we want to learn more about its safety and tolerability (effects good or bad) when used in combination with one of two other drugs (atezolizumab or durvalumab). We also want to learn more about the combination of the study drug with either atezolizumab or durvalumab and carboplatin and etopopside.

This is a study for people diagnosed with Acute Myeloid Leukemia and Myelodysplastic Syndromes who are receiving treatment with hypomethylating agents and Venetoclax. Specifically, we want to learn more about nutrition, eating, and mealtimes for older adults (age 60+) with these conditions and their care partners. Care partners can be a spouse, family member, or friend helping a patient with AML/MDS. We want to understand nutrition, eating, and mealtimes over time throughout the first two cycles of treatment. We also want to learn more about the quality of life for patients and care partners.

To determine optimal content and design features of mHealth apps for smoking cessation that are most preferred by Black and African American adults who smoke or use other tobacco products.

During puberty, adolescents grow and change a lot which may make life seem more stressful and emotional. Male and female adolescents experience the changes associated with puberty differently, possibly because of different responses to changes in hormones, including testosterone and estrogen. We are interested in learning more about the role of these hormones in regulating emotional processing and mood symptoms, and whether a mobile training program can help improve mood during the pubertal transition. Participation is 8 weeks with two monthly follow-up surveys. Compensation provided.

Have you been diagnosed with HER2 positive (HER2+) breast cancer and have recently or plan to undergo surgery? If so, you may be able to take part in a research study looking at the safety of giving two drugs trastuzumab and pertuzumab in combination with hormonal therapy after surgery for your breast cancer.

Are you an elderly patient with locally advanced Head and Neck squamous cell carcinoma who is ineligible for standard treatment involving platinum based therapy (e.g. Carboplatin or Cisplatin)? If so, you may be eligible to participate in a clinical research study involving an investigational drug, called NBTXR3.

My team and I have designed an educational website to be used by men and women who have had a recent heart attack. Our goal is for participants who join the study to use the information provided to learn how to improve their self-care to help prevent another heart attack. In order to know whether our educational program is helpful, we are looking for men and women like yourself to try using and give us feedback about it.

We are conducting a research study to use graded exposure and mobile mindfulness meditation to address clinical outcomes in individuals 6-months to 10-years post-ACLR. This will help develop effective treatments to improve outcomes after ACLR. This study will last 5 weeks. Compensation provided.

We want to learn how people's brains adapt when responding to various food stimuli and decision-making processes. We also want to learn about brain responses to food and beverage consumption. To do this, we will use taste tests, surveys, behavioral tasks, and neuroimaging (fMRI scan).

Leveraging our decades of experience studying the acute and chronic effects of traumatic brain injury (TBI) and concussion, our investigative team propose an innovative, translational approach that bridges both preclinical and clinical studies. We propose testing multiple potential preventative and therapeutic strategies in the preclinical setting, while simultaneously conducting a prospective, longitudinal study of neurologic health outcomes associated with concussion and sub-concussive exposure in former NFL players. Our prior studies of former NFL players over the past 15 years provide us with a unique opportunity to conduct a truly prospective, longitudinal study of long-term neurologic health outcomes and determine any possible association with concussion and repetitive sub-concussive exposure. In parallel, we have developed animal models of repeated concussions (repetitive mild TBI [rmTBI]) and chronic traumatic encephalopathy (CTE). We have studied the effects of readily translatable preventative and therapeutic strategies, including the N-methyl-D-aspartate (NMDA) receptor antagonist memantine, low dose carbon monoxide